Primary Information |
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| BoMiProt ID | Bomi10696 |
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| Protein Name | Zinc finger HIT domain-containing protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2TBW5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001035650.1 |
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| Aminoacid Length | 399 |
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| Molecular Weight | 42819 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNHIT2 |
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| Gene ID | 539138 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | may act as a bridging factor between the R2TP/PFDL complex and the U5 snRNP. |
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| Biochemical Properties | is a member of a conserved family of zinc finger HIT (zf-HIT) domain-containing proteins.The zf-HIT domain consists of two anti-parallel β sheets followed by two α helices packed against the second β sheet. Histidine and cysteine residues within a conserved CCCC–CCHC motif coordinate two zinc ions in an interleaved, cross-brace manner.Also contain B-box, RING and PHD, all of which mediate protein–protein interactions. |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 59-99, 146-180, 269-281 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | 1.Cloutier P, Poitras C, Durand M, Hekmat O, Fiola-Masson É, Bouchard A, Faubert D, Chabot B, Coulombe B. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Nat Commun. 2017 May 31;8:15615. doi: 10.1038/ncomms15615. PMID: 28561026; PMCID: PMC5460035. |
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