Search by BoMiProt ID - Bomi10696


Primary Information

BoMiProt ID Bomi10696
Protein Name Zinc finger HIT domain-containing protein 2
Organism Bos taurus
Uniprot IdQ2TBW5
Milk FractionWhey
Ref Sequence Id NP_001035650.1
Aminoacid Length 399
Molecular Weight 42819
Fasta Sequence https://www.uniprot.org/uniprot/Q2TBW5.fasta
Gene Name ZNHIT2
Gene Id 539138
Protein Existence Status reviewed

Secondary Information

Protein Function may act as a bridging factor between the R2TP/PFDL complex and the U5 snRNP.
Biochemical Properties is a member of a conserved family of zinc finger HIT (zf-HIT) domain-containing proteins.The zf-HIT domain consists of two anti-parallel β sheets followed by two α helices packed against the second β sheet. Histidine and cysteine residues within a conserved CCCC–CCHC motif coordinate two zinc ions in an interleaved, cross-brace manner.Also contain B-box, RING and PHD, all of which mediate protein–protein interactions.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 59-99, 146-180, 269-281
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography 1.Cloutier P, Poitras C, Durand M, Hekmat O, Fiola-Masson É, Bouchard A, Faubert D, Chabot B, Coulombe B. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Nat Commun. 2017 May 31;8:15615. doi: 10.1038/ncomms15615. PMID: 28561026; PMCID: PMC5460035.