Primary Information |
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| BoMiProt ID | Bomi10611 |
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| Protein Name | Wiskott-Aldrich syndrome protein family member 1/WASP family protein member 1/Protein WAVE-1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0IIJ3 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001029189.2 |
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| Aminoacid Length | 559 |
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| Molecular Weight | 61640 |
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| FASTA Sequence |
Download |
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| Gene Name | WASF1 |
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| Gene ID | 531488 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex |
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| PTMs | Phosphorylation and Methylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0IIJ3|WASF1_BOVIN Wiskott-Aldrich syndrome protein family member 1 OS=Bos taurus OX=9913 GN=WASF1 PE=2 SV=1
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA
TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPT
TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV
QGLPPPPPPPPLPPPGIRPSSPVTVAALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVTP
ASEPKRHPS*489TLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA
VEYSDSEDDSEFDEVDWLE
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| Predicted Disorder Regions | 170-204, 216-231, 247-249, 261-265, 310-349, 367-369, 474-486,543-559 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002). Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature, 418(6899), 790–793. https://doi.org/10.1038/nature00859 |
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