Primary Information |
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| BoMiProt ID | Bomi10567 |
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| Protein Name | WASH complex subunit 1/WAS protein family homolog 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7Z063 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001098876.1 |
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| Aminoacid Length | 471 |
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| Molecular Weight | 50773 |
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| FASTA Sequence |
Download |
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| Gene Name | WASHC1/WASH1 |
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| Gene ID | 533602 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The retromer and WASH complexes
play key roles in endosomal protein sorting and are emerging as cellular machinery that is especially important in many
neurological diseases, including PD. |
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| Biochemical Properties | The recruitment of the WASH complex to endosomes occurs through the interaction of the VPS35 protein with the extended “tail” domain of the FAM21 protein of the WASH complex |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 76-91, 110-132, 149-163, 247-249, 269-351, 378-405, 424-438, 452-471 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | RME-8, an accessory of the WASH complex and SNX dimer |
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| Bibliography | 1.Seaman MNj, Freeman CL. Analysis of the Retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease. Commun Integr Biol. 2014 Jun 13;7:e29483. doi: 10.4161/cib.29483. PMID: 25067992; PMCID: PMC4106150. |
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