Search by BoMiProt ID - Bomi10567


Primary Information

BoMiProt ID Bomi10567
Protein Name WASH complex subunit 1/WAS protein family homolog 1
Organism Bos taurus
Uniprot IdA7Z063
Milk FractionWhey
Ref Sequence Id NP_001098876.1
Aminoacid Length 471
Molecular Weight 50773
Fasta Sequence https://www.uniprot.org/uniprot/A7Z063.fasta
Gene Name WASHC1/WASH1
Gene Id 533602
Protein Existence Status reviewed

Secondary Information

Protein Function The retromer and WASH complexes play key roles in endosomal protein sorting and are emerging as cellular machinery that is especially important in many neurological diseases, including PD.
Biochemical Properties The recruitment of the WASH complex to endosomes occurs through the interaction of the VPS35 protein with the extended “tail” domain of the FAM21 protein of the WASH complex
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 76-91, 110-132, 149-163, 247-249, 269-351, 378-405, 424-438, 452-471
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments RME-8, an accessory of the WASH complex and SNX dimer
Bibliography 1.Seaman MNj, Freeman CL. Analysis of the Retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease. Commun Integr Biol. 2014 Jun 13;7:e29483. doi: 10.4161/cib.29483. PMID: 25067992; PMCID: PMC4106150.