Search by BoMiProt ID - Bomi10545


Primary Information

BoMiProt ID Bomi10545
Protein Name V-type proton ATPase subunit E 2/V-ATPase subunit E 2/Vacuolar proton pump subunit E 2
Organism Bos taurus
Uniprot IdQ32LB7
Milk FractionWhey
Ref Sequence Id NP_001073081.1
Aminoacid Length 226
Molecular Weight 26171
Fasta Sequence https://www.uniprot.org/uniprot/Q32LB7.fasta
Gene Name ATP6V1E2
Gene Id 540113
Protein Existence Status reviewed

Secondary Information

Protein Function responsible for acidifying a variety of intracellular compartments in eukaryotic cells and to facilitate activation of SMPD1(sphingomyelin phosphodiesterase 1) and consequent MR(membrane rafts) aggregation.Together these have a potential role in lysosome fusion.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Han WQ, Xu L, Tang XF, Chen WD, Wu YJ, Gao PJ. Membrane rafts-redox signalling pathway contributes to renal fibrosis via modulation of the renal tubular epithelial-mesenchymal transition. J Physiol. 2018 Aug;596(16):3603-3616. doi: 10.1113/JP275952. Epub 2018 Jul 23. PMID: 29863758; PMCID: PMC6092309.