Primary Information |
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| BoMiProt ID | Bomi10489 |
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| Protein Name | Vitrin |
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| Organism | Bos taurus |
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| Uniprot ID | Q95LI2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776396.1 |
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| Aminoacid Length | 652 |
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| Molecular Weight | 70873 |
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| FASTA Sequence |
Download |
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| Gene Name | VIT |
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| Gene ID | 280957 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | An extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration.Vitrin along with the microtubule associated protein 1 light chain 3 γ (MAP1LC3C), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M α 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia(Scrotal and Umbilical Hernia in Pigs) |
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| Biochemical Properties | Vitrin displays high structural homology with colchin and Akhirin which consists of one LCCL (Limulus factor C, Coch-5b2, and Lgl1) domain and two von Willebrand factor domains. |
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| PTMs | N-linked glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q95LI2|VITRN_BOVIN Vitrin OS=Bos taurus OX=9913 GN=VIT PE=2 SV=2
MGIVVLTMKASVIEMFLVLLVTGIQSNQEMTKKMKRPKFTVPQISCDVRAGKITNVEFIV
KCPPGCQDPRYHVYGADVYASYSSVCGAAVHSGVLDNSGGKILVRKVAGQSGYKGSYSNG
VQSLSLPRWRESFVVSEGKPQKGVTYPSSLTYSSSKSPAAKAGETARADQSPPVPGTAAQ
PVTVTQAPGTTAIEATHTTLPKPSPSAGSTASGLRPQPAGQRSKDLGEPALWKPESVLLD
AGFVPKEELSTQSLEPASQGDPSCKVDLSFLIDGSSSIGKRRFRIQKQFLTDVAQTLDIG
PAGPLMGVVQYGDNPATQFNLKTHMNSQDVKAAIEKISQRGGLSNAGRAISFVTKNFFSK
FNGNRGGAPNVAVVMVDGWPTDKVEEASRLARESGVNIFFITIEGASENEKQYMLEPNFA
NKAVCRTNGFYSLTVQNWFSLHKTVQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSV
GTSNFRTVLQFVAN*494LSREFEISDMDTRIGAMQYTYEQRLEFGFDEYSTKSDVLNAIKRVG
YWSGGTSTGAAIHYALEQLFKKSKPNKRKLMILITDGRSYDDIRIPAMLAHHKGVITYAI
GVAWAAQDELDIIATHPARDHAFFVDEFDNLYKVVPKVIQNICTEFNSQPRN
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| Predicted Disorder Regions | 146-180, 197-256 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. |
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| Bibliography | 1.Ahsan M, Ohta K, Kuriyama S, Tanaka H. Novel soluble molecule, Akhirin, is expressed in the embryonic chick eyes and exhibits heterophilic cell-adhesion activity. Dev Dyn. 2005 May;233(1):95-104. doi: 10.1002/dvdy.20303. PMID: 15765510. 2.Rodrigues AFG, Ibelli AMG, Peixoto JO, Cantão ME, Oliveira HC, Savoldi IR, Souza MR, Mores MAZ, Carreño LOD, Ledur MC. Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs. Genes (Basel). 2021 Jan 27;12(2):166. doi: 10.3390/genes12020166. PMID: 33513662; PMCID: PMC7912685. |
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