Search by BoMiProt ID - Bomi10429


Primary Information

BoMiProt ID Bomi10429
Protein Name Urocortin-3/Urocortin III/Ucn III
Organism Bos taurus
Uniprot IdQ1RMJ9
Milk Fractionwhey
Ref Sequence Id NP_001069995.1
Aminoacid Length 166
Molecular Weight 17849
Fasta Sequence https://www.uniprot.org/uniprot/Q1RMJ9.fasta
Gene Name UCN3/SPC
Gene Id 751573
Protein Existence Status Reviewed

Secondary Information

Protein Function Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress
Biochemical Properties The C-terminal sequence of both human and mouse Ucn III peptides contains a pair of basic residues, RK for the human and KK for the mouse, immediately preceded by a glycine, presumed to be involved in C-terminal amidation.
PTMs Amydation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-126, 144-166
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., Bilezikjian, L., Rivier, J., Sawchenko, P. E., & Vale, W. W. (2001). Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proceedings of the National Academy of Sciences of the United States of America, 98(13), 7570–7575. https://doi.org/10.1073/pnas.121165198 2.Zhang, X., Liu, Y., Qi, J., Tian, Z., Tang, N., Chen, D., & Li, Z. (2019). Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models. Peptides, 121, 170124. https://doi.org/10.1016/j.peptides.2019.170124