Search by BoMiProt ID - Bomi10267


Primary Information

BoMiProt ID Bomi10267
Protein Name Ubiquitin-like-conjugating enzyme ATG3/Autophagy-related protein 3
Organism Bos taurus
Uniprot IdQ0VCL3
Milk FractionExosomes
Ref Sequence Id NP_001068832.1
Aminoacid Length 314
Molecular Weight 35752
Fasta Sequence https://www.uniprot.org/uniprot/Q0VCL3.fasta
Gene Name ATG3
Gene Id 508571
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells blood
Protein Function ATG3 acts as an E2 ubiquitin-like conjugating enzyme in the ATG8 conjugation system, contributing to phagophore elongation. ATG3 has also been found to participate in many physiological and pathological processes in an autophagy-dependent manner, such as tumor occurrence and progression, ischemia-reperfusion injury, clearance of pathogens, and maintenance of organelle homeostasis.
PTMs N-Acetylation at Meth, Isopeptide bond formation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 92-177
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy
Additional Comments Overexpression of ATG3 could facilitate the formation of the ATG12–ATG5 complex in humans.
Bibliography 1.Fang D, Xie H, Hu T, Shan H, Li M. Binding Features and Functions of ATG3. Front Cell Dev Biol. 2021 Jun 21;9:685625. doi: 10.3389/fcell.2021.685625. PMID: 34235149; PMCID: PMC8255673. 2.Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, Kominami E J Biol Chem. 2002 Apr 19; 277(16):13739-44. 3.The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M.Mol Biol Cell. 2008 Nov; 19(11):4762-75.