Search by BoMiProt ID - Bomi10266


Primary Information

BoMiProt ID Bomi10266
Protein Name Ubiquitin-fold modifier-conjugating enzyme 1
Organism Bos taurus
Uniprot IdQ5E953
Milk FractionExosomes
Ref Sequence Id NP_001015663.1
Aminoacid Length 167
Molecular Weight 19431
Fasta Sequence https://www.uniprot.org/uniprot/Q5E953.fasta
Gene Name UFC1
Gene Id 537221
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells thyroid gland
Protein Function Ufc1 is one of the enzymes involved in modification of proteins with the ubiquitin-like molecule ubiquitin-fold modifier-1 (Ufm1).Ufc1 participates in the very recently discovered Ufm1-Uba5-Ufc1 ubiquination pathway which is found in metazoan organisms.
Biochemical Properties Ufc1 structure consists of the catalytic core domain conserved in all E2-like enzymes and an additional N-terminal helix. 
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-8, 160-167
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. J Struct Funct Genomics. 2009 Apr;10(2):127-36. doi: 10.1007/s10969-008-9054-7. Epub 2008 Dec 20. PMID: 19101823; PMCID: PMC2850604. 2.Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S. Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1). Exp Cell Res. 2014 Jun 10;324(2):192-9. doi: 10.1016/j.yexcr.2014.04.003. Epub 2014 Apr 12. PMID: 24726913.