Search by BoMiProt ID - Bomi10189


Primary Information

BoMiProt ID Bomi10189
Protein Name U6 snRNA-associated Sm-like protein LSm8
Organism Bos taurus
Uniprot IdQ3ZCE0
Milk Fractionwhey
Ref Sequence Id NP_001029912.1
Aminoacid Length 96
Molecular Weight 10403
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZCE0.fasta
Gene Name LSM8
Gene Id 613630
Protein Existence Status Reviewed

Secondary Information

Protein Function The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.LSm proteins may play a role in U4/U6 snRNP formation.
Biochemical Properties Conserved "Sm motif".The Sm motif is relatively degenerate and consists of two parts, termed Sm1 and Sm2 domains, which are often separated by a large loop region.form seven-member ring structures that interact with RNA.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-4, 80-84, 86-96
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J. 1999 Oct 15;18(20):5789-802. doi: 10.1093/emboj/18.20.5789. PMID: 10523320; PMCID: PMC1171645.