Search by BoMiProt ID - Bomi10128


Primary Information

BoMiProt ID Bomi10128
Protein Name Tubulin-specific chaperone D/Beta-tubulin cofactor D/Tubulin-folding cofactor D
Organism Bos taurus
Uniprot IdQ28205
Milk FractionWhey
Ref Sequence Id NP_776619.1
Aminoacid Length 1199
Molecular Weight 133014
Fasta Sequence https://www.uniprot.org/uniprot/Q28205.fasta
Gene Name TBCD
Gene Id 281515
Protein Existence Status reviewed

Secondary Information

Protein Function Required for Maintaining the Microtubule Network
Biochemical Properties The model for tubulin folding includes the TBCD/TBCE/α-tubulin/β-tubulin tetramer as the penultimate complex to which TBCC binds, resulting in release of the folded αβ-tubulin heterodimer.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions 1-24, 342-357
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Francis JW, Newman LE, Cunningham LA, Kahn RA. A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network. J Biol Chem. 2017 Mar 10;292(10):4336-4349. doi: 10.1074/jbc.M116.770909. Epub 2017 Jan 26. PMID: 28126905; PMCID: PMC5354482.