Primary Information |
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| BoMiProt ID | Bomi10128 |
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| Protein Name | Tubulin-specific chaperone D/Beta-tubulin cofactor D/Tubulin-folding cofactor D |
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| Organism | Bos taurus |
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| Uniprot ID | Q28205 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776619.1 |
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| Aminoacid Length | 1199 |
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| Molecular Weight | 133014 |
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| FASTA Sequence |
Download |
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| Gene Name | TBCD |
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| Gene ID | 281515 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Required for Maintaining the Microtubule Network |
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| Biochemical Properties | The model for tubulin folding includes the TBCD/TBCE/α-tubulin/β-tubulin tetramer as the penultimate complex to which TBCC binds, resulting in release of the folded αβ-tubulin heterodimer. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-24, 342-357 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Francis JW, Newman LE, Cunningham LA, Kahn RA. A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network. J Biol Chem. 2017 Mar 10;292(10):4336-4349. doi: 10.1074/jbc.M116.770909. Epub 2017 Jan 26. PMID: 28126905; PMCID: PMC5354482. |
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