Search by BoMiProt ID - Bomi10121


Primary Information

BoMiProt ID Bomi10121
Protein Name Tubulin polymerization-promoting protein/25 kDa brain-specific protein/p25-alpha
Organism Bos taurus
Uniprot IDQ27957
Milk FractionWhey
Ref Sequence ID NP_776401.1
Aminoacid Length 218
Molecular Weight 23473
FASTA Sequence Download
Gene Name TPPP
Gene ID 280968
Protein Existence Status reviewed

Secondary Information

Protein Function It is involved in regulation of microtubule dynamics, posessing important function in myelination by bringing about elongation of the myelin sheath.
PTMs Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q27957|TPPP_BOVIN Tubulin polymerization-promoting protein OS=Bos taurus OX=9913 GN=TPPP PE=1 SV=1 MADSRPKPANKT*12PPKS*16PGEPAKDKAAKRLS*30LEAEGAGEGAAAAGAELSALEEAFRKFAVH GDARASGREMHGKNWSKLCRDCQVIDGRSVT*91VTDVDIVFSKIKGKS*106CRTITFEQFKEALE ELAKKRFKDKSAEEAVREVHKLIEGKAPIIS*151GVTKAIS*158S*159PTVSRLTDTSKFTGSHKERFD PSGRGKGRAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
Predicted Disorder Regions (1-46), (56-74), (125-134), (160-218)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylated by LIMK1 on serine residues; phosphorylation may alter the tubulin polymerization activity.
Bibliography Oláh, J., Tokési, N., Vincze, O., Horváth, I., Lehotzky, A., Erdei, A., Szájli, E., Medzihradszky, K. F., Orosz, F., Kovács, G. G., & Ovádi, J. (2006). Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. FEBS letters, 580(25), 5807–5814. https://doi.org/10.1016/j.febslet.2006.09.037