Search by BoMiProt ID - Bomi10014


Primary Information

BoMiProt ID Bomi10014
Protein Name Transmembrane protein 47/Transmembrane 4 superfamily member 10
Organism Bos taurus
Uniprot IdQ1JPA3
Milk FractionWhey,MFGM
Ref Sequence Id NP_001069730.1
Aminoacid Length 181
Molecular Weight 19998
Fasta Sequence https://www.uniprot.org/uniprot/Q1JPA3.fasta
Gene Name TMEM47/TM4SF10
Gene Id 541164
Protein Existence Status reviewed

Secondary Information

Protein Function TMEM47 may be a useful biomarker for predicting the response to chemotherapy and a potential therapeutic target for overcoming HCC chemoresistance.
Biochemical Properties TMEM98, which is implicated in the chemoresistance of hepatocellular carcinoma (HCC) via regulating the AKT and P53 pathways.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
na
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 4TMHs; (21-43), (82-104), (117-135), (154-172)
Additional Comments TMEM47 is one of the protein found to be overexpressed in metastatic breast cancer cells.
Bibliography 1.Ng KT, Yeung OW, Liu J, Li CX, Liu H, Liu XB, Qi X, Ma YY, Lam YF, Lau MY, Qiu WQ, Shiu HC, Lai MK, Lo CM, Man K. Clinical significance and functional role of transmembrane protein 47 (TMEM47) in chemoresistance of hepatocellular carcinoma. Int J Oncol. 2020 Oct;57(4):956-966. doi: 10.3892/ijo.2020.5104. Epub 2020 Jul 28. PMID: 32945373; PMCID: PMC7473756. 2.Burnett RM, Craven KE, Krishnamurthy P, Goswami CP, Badve S, Crooks P, Mathews WP, Bhat-Nakshatri P, Nakshatri H. Organ-specific adaptive signaling pathway activation in meta-static breast cancer cells. Oncotarget. 2015;6:12682–12696. doi: 10.18632/oncotarget.3707. 3.Ng KT, Lo CM, Guo DY, Qi X, Li CX, Geng W, Liu XB, Ling CC, Ma YY, Yeung WH, et al. Identification of transmembrane protein 98 as a novel chemoresistance-conferring gene in hepatocellular carcinoma. Mol Cancer Ther. 2014;13:1285–1297. doi: 10.1158/1535-7163.MCT-13-0806.