Primary Information
BoMiProt ID	Bomi10014
Protein Name	Transmembrane protein 47/Transmembrane 4 superfamily member 10
Organism	Bos taurus
Uniprot ID	Q1JPA3
Milk Fraction	Whey,MFGM
Ref Sequence ID	NP_001069730.1
Aminoacid Length	181
Molecular Weight	19998
FASTA Sequence	Download
Gene Name	TMEM47/TM4SF10
Gene ID	541164
Protein Existence Status	reviewed
Secondary Information
Protein Function	TMEM47 may be a useful biomarker for predicting the response to chemotherapy and a potential therapeutic target for overcoming HCC chemoresistance.
Biochemical Properties	TMEM98, which is implicated in the chemoresistance of hepatocellular carcinoma (HCC) via regulating the AKT and P53 pathways.
PTMs	Acetylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	4TMHs; (21-43), (82-104), (117-135), (154-172)
Additional Comments	TMEM47 is one of the protein found to be overexpressed in metastatic breast cancer cells.
Bibliography	1.Ng KT, Yeung OW, Liu J, Li CX, Liu H, Liu XB, Qi X, Ma YY, Lam YF, Lau MY, Qiu WQ, Shiu HC, Lai MK, Lo CM, Man K. Clinical significance and functional role of transmembrane protein 47 (TMEM47) in chemoresistance of hepatocellular carcinoma. Int J Oncol. 2020 Oct;57(4):956-966. doi: 10.3892/ijo.2020.5104. Epub 2020 Jul 28. PMID: 32945373; PMCID: PMC7473756. 2.Burnett RM, Craven KE, Krishnamurthy P, Goswami CP, Badve S, Crooks P, Mathews WP, Bhat-Nakshatri P, Nakshatri H. Organ-specific adaptive signaling pathway activation in meta-static breast cancer cells. Oncotarget. 2015;6:12682–12696. doi: 10.18632/oncotarget.3707. 3.Ng KT, Lo CM, Guo DY, Qi X, Li CX, Geng W, Liu XB, Ling CC, Ma YY, Yeung WH, et al. Identification of transmembrane protein 98 as a novel chemoresistance-conferring gene in hepatocellular carcinoma. Mol Cancer Ther. 2014;13:1285–1297. doi: 10.1158/1535-7163.MCT-13-0806.