Primary Information |
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| BoMiProt ID | Bomi10000 |
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| Protein Name | Transmembrane protein 168 |
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| Organism | Bos taurus |
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| Uniprot Id | A0JNG0 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001071499.1 |
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| Aminoacid Length | 697 |
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| Molecular Weight | 79785 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A0JNG0.fasta |
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| Gene Name | TMEM168 |
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| Gene Id | 541075 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Probably involved in cell cycle regulation.One report says that due to the knockdown of TMEM168 ,there is induced cell cycle arrest (G0/G1 phase) and promoted apoptosis, and the mechanisms involved in blocking Wnt/β-catenin pathway. |
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| Biochemical Properties | comprises 697 amino acid residues, including some putative transmembrane domains |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A0JNG0|TM168_BOVIN Transmembrane protein 168 OS=Bos taurus OX=9913 GN=TMEM168 PE=2 SV=1
MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTA
NSLILVIFILGLFVLGIASILYYYFSMETASLSLSNLWFGFLLGFLCFLDN*111SSFKNDVKE
ESTKYLLLTSIVLRILCSLVERMSGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSV
ILLVVALAMLIIDLRMKSFLALPNLVIFAVLLFFSSLETPKNPVAFACFFICLITDPFLD
IYFSGLSVTERWKPFLYRGRICRRLSVVFTGMIELTFFILSAFKLRDTHLWYFVIPGFSI
FGIFWMICHIIFLLTLWGFHTKLNDCHKVCFTHRVDN*337NSLDRIMASKGMRHFCLISEQLV
FFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGSCLGGTSVGYAIVIPT
NFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSK
LKAFLELRTVDGPRHDTYVLYYSGHTHGTGEWALAGGDILRLDTLLEWWREKN*533GSFCSRL
IIILDSENSTPWVKEVRKINDQYIAVQGAEMTKTIDIEEADPPQLGDFTKDWVEYNCN*598TT
NNICWTEKGRTVKAIYGVSKRWSDYTLHLPTGSDVAKHWMLYFPRITYPLVHLANWLCGL
NLFWICKTCFRCLKRLKMSWFLPAVLDTGQGFKLVKS
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 10TMHs; (36-54), (63-85), (92-114), (170-192), (199-217) (223-245), (265-283),(298-320), (359-377), (647-665) |
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| Bibliography | Xu J, Su Z, Ding Q, Shen L, Nie X, Pan X, Yan A, Yan R, Zhou Y, Li L, Lu B. Inhibition of Proliferation by Knockdown of Transmembrane (TMEM) 168 in Glioblastoma Cells via Suppression of Wnt/β-Catenin Pathway. Oncol Res. 2019 Jul 12;27(7):819-826. doi: 10.3727/096504018X15478559215014. Epub 2019 Mar 25. PMID: 30940290; PMCID: PMC7848296. |
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