Browse BoMiProt


Database of bovine milk proteins

BoMiProt
Id.
Uniprot
ID
Protein Gene
Name
Gene
ID
Milk
Fraction
PTMs
Bomi1 Q0VCM5 Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 508356 Whey Glycosylated: two potential N-glycosylation sites of H1 are effectively fully occupied by complex-type N-glycans- predominantly of biantennary type; H2 heavy chain carries only one complex-type N-glycan attached to Asn64; O-glycan carried by Thr637, two or three additional O-linked carbohydrate chains are present on H2-consist of a type-1 core structure with one or two NeuAc moieties;
Bomi10 P17697 Clusterin CLU 280750 Whey heavy glycosylation; carbohydrate comprises approximately 20-25% of the total mass of the mature molecule; six N-linked glycosylation sites have been identified, three in the alpha chain (α64N, α81N, and α123N) and three in the beta chain (ß64N, ß127N, and ß147N); types of oligosaccharides attached to the clusterin peptide are diverse;
Bomi100 P01035 Cystatin-C CST3 281102 Whey 2 intracellular disulfide bonds; no glycosylation; chicken cystatin is phosphorylated;
Bomi101 P01044 Kininogen-1 KNG1 280833 Whey Bovine fragment 1.2 of HMW kininogen has four oligosaccharide chains that attached to serine and threonine residues. The residues with oligosaccharide chains are S10, T10, T12, S18 from the amino-terminal of the fragment 1.2;
Bomi102 P01888 Beta-2-microglobulin B2M 280729 Whey incubating normal ß2M with glucose produces advanced glycatione end products that make ß2M more acidic- promotes amyloidosis
Bomi103 P02662 Alpha-S1-casein CSN1S1 282208 Whey Phosphoprotein; nine phosphorylated serine residues and a highly negatively charged region including residues 41-77
Bomi104 P02663 Alpha-S2-casein CSN1S2 282209 Whey Phosphorylated; 11 phosphorylated serine residues; phosphorylated residues varies from 10 to 13 minor degrees of intermolecular disulfide bonding
Bomi105 P02666 Beta-casein CSN2 Whey Phosphorylated; presence of 5 phosphates in bovine; site of phosphorylation: Ser-Xxx-Glu/pSer; of 12 genetic variants of β -casein in bovine only two variants appear to have altered phosphorylation; Equine β -casein shows variation in phosphorylation, with typically 3 to 7 phosphates on full-length β -casein; the β -casein of human milk exists as six different forms with 0 to 5 phosphates; Ovine β -casein has variable phosphorylation, with 0 to 7 phosphates
Bomi106 P02676 Fibrinogen beta chain FGB Whey Glycosylated; biantennary oligosaccharides; sialic acids vary in the normal subpopulation of fibrinogen polypeptide as found in humans; sialic acids linkage in monosialylated sugars is either on 90% Manα(l -3) side and 10% on the Manα(1-6) side ;
Bomi110 P12763 Alpha-2-HS-glycoprotein AHSG 280988 Whey three potential N-glycosylation sites identified in mouse AHSG are conserved in bovine fetuin, while only two of them are conserved in human AHSG; in humans A-chain of a2HS contains 2 biantennary N- and 2 O-linked glycans; N-glycan has a2-6 NeuAc residues, 4 Gal, αMan, N glycans are partially (~90%) sialylated; O-glycans have partially sialylated 2.5 α2-3-linked NeuAc; 3 0-trisaccharides have the structure NeuAcα2-3Gal01-3GalNAcαl- 0
Bomi112 P15497 Apolipoprotein A-I APOA1 281631 Whey Lipoprotein; forty-four residue consensus sequence peptides (ABAB), real sequence peptides, RSP-1 (H4–5) and RSP-2 (H5–H6) were studied in plasma. RSP-1 exhibited higher lipid affinity than RSP-2 in terms of helical structure induced by detergent, suggesting that H4 has higher lipid-binding affinity than H6; little difference was seen in the α-helical content or lipid affinity of the larger vs. the 22-mer peptides, indicating that the individual domains do not fold/bind lipid cooperatively;
Bomi113 P18892 Butyrophilin subfamily 1 member A1 BTN1A1 282157 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi115 P23805 Conglutinin CGN1 281068 Whey presence of O-linked glycans of β(1-3)-GalNAc and α-(2-3) linked sialic acid type. No N-linked glycans were detected
Bomi116 P24627 Lactotransferrin LTF 280846 Whey Glycosylated; 5 N-linked glycans; mixtures of high mannose, complex and hybrid type; 59 different structures have been identified till date; fucosylated and sialylated; presence of unusual motifs including N,N'-diacetyllactosamine as found in bovine milk
Bomi119 P31096 Osteopontin SPP1 281499 Whey Phosphorylated glycoprotein; ~25 phosphates distributed over 36 potential sites in human milk osteopontin; ~22 phosphates distributed over 28 potential sites in bovine milk osteopontin; Bovine milk OPN contains three O-glycosylated threonine residues close to the integrin binding motifs; The glycan structures on human milk OPN have been shown to consist of large fucosylated N-acetyllactosamine units; the carbohydrates on bovine OPN consist of a disialylated GalNAc-galactose cores
Bomi121 P34955 Alpha-1-antiproteinase SERPINA1 280699 Whey glycosylation at three distinct asparagine residues; These asparagine-linked side chains are composed of N-acetylglucosamine, mannose, galactose, and sialic acid arranged as a core with two to three branching “antennae”
Bomi123 P42916 Collectin-43 CL43 431784 Whey CL -43 does not posses N-linked carbohydrate, but it contains hydroxylysine residues in the collagen-like region that are potential O-glycosylation sites
Bomi124 P48616 Vimentin VIM 280955 Whey Sumoylation by ubc9; glycosylation by OGT, O-linked β-N-acetylglucosamine; ADP ribosylation by ADP-ribosyl transferase SpyA; numerous phosphorylation sites
Bomi125 P52193 Calreticulin CALR 281036 Whey Depending on species, calreticulin may have one or more potential N-linked glycosylation sites; The glycosylation pattern of the protein seems to be heterogeneous and does not appear to be a conserved property of the protein. The glycosylation of calreticulin is more common in plants than in animal cells; bovine liver calreticulin appears to be glycosylated with two potential N-linked glycosylation sites; carbohydrate composition, GlcNac2Man4 -9 with GlcNAc2Man5 being most abundant in bovine brain calreticulum; rat liver protein is glycosylated with complex hybrid type of oligosaccharide with a terminal galactose residue
Bomi131 P80025 Lactoperoxidase LPO 280844 Whey glycoprotein; four to five N-glycosylation sites and are characterizedby a carbohydrate content of about 10 %;
Bomi132 P80929 Angiogenin2 ANG2 Whey cross-linked by three disulfide bonds, is glycosylated at Asn33; contained 5 - 6 mannose, 2- 3 glucosamine, 1-2 galactosamine, up to one xylose and no sialic acid residues;
Bomi133 P81187 Complement factor B CFB 514076 Whey Glycosylated; glucose is covalently attached; sialylated complex biantennary sugars
Bomi134 P81265 Polymeric immunoglobulin receptor PIGR 281401 Whey Heavily N-glycosylated; contains glucose, N-acetylglucosamine, N-acetylgalactosamine. and N-acetylneuraminic acid as detected in human colustrum
Bomi136 Q0IIH5 Nucleobindin 2 NUCB2 509003 Whey Phosphorylated as found in gastric mucosa; might be glycosylated
Bomi137 Q0III8 RNASET2 protein (Fragment) RNASET2 508245 Whey glycosylated in eukaryotic cells- glucose, mannose, glucosamine, galactose and xylose
Bomi138 Q0VCX2 78 kDa glucose-regulated protein HSPA5 415113 Whey mammalian BiP exists in interconvertible monomeric and oligomeric forms and can be post-translationally modified by phosphorylation and by ADP ribosylation
Bomi139 Q17QK3 Carboxypeptidase Q CPQ 540923 Whey heavily N- and Oglycosylated - ten N-glycosylation sites predicted within the primary sequence of human GCPII
Bomi14 P25326 Cathepsin S CTSS 327711 Whey potential glycosylation sites are located in the propeptide at position Asn104 in the human enzyme; Asn100 as well as Asn110 in the rat enzyme; Human cathepsin S contains three disulfide bonds (Cys136-Cys180, Cys170-Cys213, Cys272-Cys320). Cys139, His278 and Asn298
Bomi140 Q28178 Thrombospondin-1 THBS1 281530 Whey Glycosylated; contains neutral sugars, amino sugars, sialic acids;
Bomi141 Q29443 Serotransferrin TF 280705 Whey Glycosylated; carbohydrate content varies from 3 to 11.8% of total protein weight; biantennary structure; presence of branched, hetero N-glycan chains; each glycan consists of two sialic acid, two galactose, three mannose and four N-acetylglucosamine residues;
Bomi142 Q2KIF2 Leucine-rich alpha-2-glycoprotein LRG1 514663 Whey has two intrachain disulfide bonds; one galactosamine and four glucosamine oligosaccharides attached;
Bomi144 Q2KIS7 Tetranectin CLEC3B 515783 Whey contains a long-form carbohydrate recognition domain with three disulfide bridges
Bomi145 Q2KJF1 Alpha-1B-glycoprotein A1BG 518955 Whey single polypeptide chain N-linked to four glucosamine oligosaccharides; All four glucosamine oligosaccharides are attached to asparagine in the obligate tripeptide acceptor sequence Asn-Xaa-Ser/Thr, in which Xaa is almost any amino acid; five intrachain disulfide bonds
Bomi146 Q2TBU0 Haptoglobin HP 280692 Whey Acidic glycoprotein tetramer; β-chain contains four N-glycosylation sites at Asn184, Asn207, Asn211 and Asn241; increased O-glycosylation like fucosylation was revealed in different diseases; fucosylation and sialylation have been reported to influence ligand–receptor interactions as found in humans
Bomi147 Q2UVX4 Complement C3 C3 280677 Whey Glycosylated; N-linked high-mannose carbohydrate moieties are attached at residues 917 of the α-chain and 63 of the ß-chain
Bomi148 Q3MHN5 Vitamin D-binding protein GC 530076 Whey Glycosylated; GC1 forms have glycosylations at positions 418 and 420, whereas GC2 has glycosylation only at 418; trisaccharides as most frequent in GC1 with lesser amounts of disaccharides as found in humans
Bomi150 Q3SZ57 Alpha-fetoprotein AFP 506011 Whey glycoprotein; bAFP in FBS is approximately evenly divided between Con A reactive and non-reactive variants; bAFP in amniotic fluid from an early gestation animal exhibited 72% reactive and 28% non-reactive variants
Bomi152 Q3SZR3 Alpha-1-acid glycoprotein ORM1 497200 Whey A glycoprotein; carbohydrate moiety accounting for 26.6% of its molecular weight; presence of sialic acid-containing diantennary oligosaccharides which is composed of only N-glycolylneuraminic acid as reported in bovine milk; presence of 2 isoforms in milk, one from mammary galnd and another from somatic cells; isoforms share a similar content of sialic acid a(2-3)- and a(2-6)-linked to galactose; somatic cells produce AGP isoforms that are strongly fucosylated and contain an elevated number of diantennary glycans; in humans the protein has five N-linked glycans; different degrees of branching; structurally heterogeneous due to the great diversity of the terminating sugars;
Bomi153 Q3T004 Serum amyloid P-component APCS 514488 Whey Glycosylated; a single N-linked biantennary oligosaccharide attached to Asn32
Bomi154 Q3ZBX0 Basigin BSG 508716 Whey Members of CD147 family, EMMPRIN, basigin, 5A11/HT7 from different species, tissues or cells appear as diverse glycosylated forms, with large variation in molecular weight. Basigin in human, mouse and chicken has three Asn glycosylation sites to which high mannose-type and complex-type glycans are linked; High mannose-type glycans are composed of mannose and N-acetylglucosamine, while complextype glycans have outer chains containing sialic acid, galactose and N-acetylglucosamine. Importantly, poly- N-acetyllactosamine (a repeating structure of galactose and N-acetylglucosamine) is present in an outer chain, the so-called b1,6-branch, of BSG glycans; CD147 exhibited both high-mannose type and bi-antennary complex-type oligosaccharides; presence of β1,6-branched oligosaccharides, the sialyl Lewis X structure, namely, Galβ1, 4Fucα1,3GlcNAc, in N-glycans of CD147 ;
Bomi155 Q3ZCH5 Zinc-alpha-2-glycoprotein AZGP1 508800 Whey Glycosylated; typical N-linked biantennary structure,substituted with N-acetylneuraminic acid in a 2,6 linkage and lacks fucose; 4 putative glycosylation sites; Asn 89, 92,106, 239; Asn 89,106, 239 carry glucosamines; Asn 239 is heavilly silalylated on mannose 2,6 arm;
Bomi157 Q5E9F7 Cofilin -1 CFL1 534553 Whey Cofilin oxidation leads to formation of intramolecular disulfide bonds and to dephosphorylation at Ser3 ; phosphorylation at Ser3 for role in actin filament dynamics
Bomi159 Q7SIH1 Alpha-2-macroglobulin A2M 513856 Whey Glycosylayted; 4 identical subunits have 8-N glycosylated sites in each subunit as found in humans;
Bomi16 P28800 Alpha-2-antiplasmin SERPINF2 282522 Whey Human α 2-antiplasmin Glycosylated; 11% to 14% carbohydrate (four putative N-linked glycosylation sites at asparagine residues 99, 268, 282, and 289) and a sulfated tyrosine residue at position 457; contains 1 disulfide bridge (between the cysteine residues in positions 43 and 116; 70% of circulating protein is N-terminally cleaved between the proline residue at position 12 and the asparagine residue at position 13; 30% circulatates with a methionine (Met) residue at the N terminus;
Bomi160 Q8MHZ9 Collectin-46 CL46 415114 Whey Potential N-glycosylation site is localized at asparagine 90 in the collagen-like region
Bomi161 Q8MI01 Mucin 15 MUC15 337919 Whey Heavily O-glycosylated; glycans are composed of fucose, galactose, mannose, N-acetylgalactosamine, N-acetylglycosamine, and sialic acid; hybrid-type N-glycans - sialylated and contain terminal poly-lactosamine structures; O-linked glycans were found to constitute some unsubstituted Core- 1 structures and a substantial number of sialylated Core-1 O-linked glycans; complex O-glycans contain high amounts N-acetylglucosamine residues and a small subset of is decorated with lactosamine on their terminal ends
Bomi162 Q8WML4 Mucin 1 MUC1 281333 Whey glycoprotein; 50% carbohydrate, 30% of which was sialic acid; polymorphic and carbohydrate portion is of variable nature; serine and threonine hydroxyls provide sites for glycosylation; human milk MUC1 has high galactose, modest level of sialic acid, and lack of detectable mannose; bovine MUC1 has less galactose, significant mannose and much higher sialic acid; galactose and N-acetylglucosamine are the dominant sugars in the human mucin; O-linked oligosaccharides are comprised of a core unit attached to MUCl via N-acetylgalactosamine, a backbone, and a terminal region; The core and backbone may be branched and the ends may be terminated by sialic acid, galactose, fucose or N-acetylgalactosamine; Sulfation may also occur at the periphery;
Bomi163 Q95114 Lactadherin MFGE8 281913 Whey Glycosylated; contained galactose, N-acetylgalactosamine and fucose, and which was 0- linked to Ser9 in PAS-6 and to Thr16 in PAS-7 as detected in bovine MFG; N and O-glycosylated depending on different isoforms found in mouse mammary gland
Bomi164 Q9N2I2 Plasma serine protease inhibitor SERPINA5 338050 Whey single-chain glycoprotein; five putative glycosylation sites: three Asn-X-Ser/Thr sequences and two Thr/Ser-X-X-Pro.
Bomi167 Q9TUM6 Perilipin-2 PLIN2 280981 Whey phosphorylated
Bomi168 A0JNE0 SPARC related modular calcium binding 1 SMOC1 508379 Exosome three predicted N-glycosylation sites- Asn-153, Asn-214, and Asn-374
Bomi17 P31976 Ezrin EZR 281574 Whey Phosphorylated; C-terminal threonine phosphorylation
Bomi172 A2VDW7 Solute carrier organic anion transporter family, member 1A2 SLCO1A2 282472 Exosome when expressed in HeLa cells, five putative N-glycosylation sites were identified, including Asn residues at the amino acid positions of 62, 124, 412, and 483 as well as the 135 position
Bomi176 A4IFC8 DNA ligase LIG1 100124507 Exosome at least three potential phosphorylation sites for CKII; Two of these are located in the N-terminal region of the enzyme outside the catalytic domain, whereas the third occurs within an evolutionarily conserved region just over a hundred amino acid residues from the C-terminus of the enzyme
Bomi177 A4IFN6 SNX18 protein SNX18 538366 Exosome serine/threonine phosphorylation
Bomi180 A5PJQ1 DEK protein DEK 540945 MFGM phosphoprotein- several phosphorylation sites of which most are clustered in the carboxy-terminal region- phosphorylation, mediated by CK2 kinase
Bomi184 A5PKL2 RRAS2 protein RRAS2 519269 MFGM, Exosome exhibited increased lysine fatty acylation in mouse embryonic fibroblast and Human Embryonic Kidney
Bomi186 A6H7D4 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta) AGPAT6 511614 MFGM, Exosome in humans, predicted N-glycosylation site (Asn-59) and O-glycosylation sites (Thr- 233, Thr-262; predicted protein kinase phosphorylation sites (Thr-174)
Bomi19 P62157 Calmodulin CALM 617095 Whey Trimethyllysine, which is amino acid residue 115 in beef calmodulin, occurs as the result of posttranslational N-methylation catalyzed by S-adenosylmethionine:calmodulin (lysine) N-methyltransferase; substrate for protein carboxylmethyltransferase; calmodulin converting enzyme clips the carboxyl terminal lysine from calmodulin; undergoes acetylation of its N-terminal amino acid residue (alanine)4
Bomi190 A6QNW8 CD97 molecule ADGRE5 MFGM, Exosome contains 8 potential N-glycosylation sites.The first 2 sites are located within the first EGF domain, the thirdsite within the second EGF domain. The other 5 sites are locatedwithin the stalk
Bomi193 A6QQP5 SPN protein SPN 614645 MFGM transmembrane sialoglycoprotein- N-glycan (2) shown in this study to be attached to peptide PaPr-1, which contains Asn-220, the only site in the Galgp and CD43 amino acid sequence with the characteristic tripeptide, Asn-Xaa-(Ser or Thr), leading to N-glycosylation. Peptide PaPr-1 was shown earlier by NMR spectroscopic analysis to possess a fucosylated diantennary glycan (2). N-glycosylation has been demonstrated for human CD43 (6, 17), but the structure of the CD43 N-glycan has not been identified; high density of O-glycans - glycosylation status was defined for 28 of the serine and threonine residues, of which 25 have O-glycans and 3 were shown to be nonglycosylated (Fig. 1). If this glycosylated to nonglycosylated ratio applies throughout the molecule, Galgp, which has 92 serine plus threonine residues, would contain -82 O-glycans. In the case of CD43, estimates based on compositional data (human and rat CD43; refs. 4-6) and peptide sequence (rat CD43; ref. 21) yield values of >75 O-glycans per molecule; 0-glycans, expressing predominantly tetrasaccharides in the case of circulating T lymphocyte and monocyte CD43 and the above hexasaccharide in the case of neutrophil, platelet, and activated T-lymphocyte CD43
Bomi196 A7E3T1 CD151 antigen CD151 523328 Exosome glycosylation sites in EC2 domain
Bomi199 A7Z024 RP2 protein RP2 534054 MFGM, Exosome Contains both myristoylation and palmitoylation sites in its N‐terminal end- As found in humans, Met-Gly-Cys-X-Phe-Ser-Lys N-terminal motif
Bomi2 F1MSZ6 Antithrombin-III SERPINC1 Whey Glycosylated: single chain glycoprotein; 4 glycosylation sites in human ATIII. Three of them, Asn96, 155 and 192, have been identified in the bovine ATIII sequence.The secreted human ATIII contains 432 amino acids, 6 of which are cysteines that form 3 disulfide bridges which are conserved in the bovine protein: Cys8-Cys128, Cys21-Cys95, Cys247- Cys430
Bomi203 A8PVV5 SYPL1 protein SYPL1 615728 MFGM acidic glycoprotein
Bomi204 Q4GZT4 ATP-binding cassette sub-family G member 2 ABCG2 536203 MFGM, Exosome intermolecular disulfide bond at position 603
Bomi209 P46446 Aspartoacylase ASPA Exosome A putative N-glycosylation site (Asn117) contained in an Asn-X-Thr/Ser recognition sequence; located adjacent to one of the proposed histidine metal ion ligands
Bomi2098 Q9MZ06 Fibroblast growth factor-binding protein 1 FGFBP1 281812 Whey, Exosome glycosylation sites revealed the presence of glycans on Asn155 and Ser172
Bomi210 Q10741 Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 282132 Whey, Exosome As found in bovine ADAM 10, four potential N-glycosylation sites (N267, N278, N439 and N551); contain high-mannose and complex-type glycans; three located in the metalloprotease domain (N267, N278 and N439) and one in the disintegrin domain (N551)
Bomi213 P20000 Aldehyde dehydrogenase, mitochondrial ALDH2 508629 MFGM cytosolic ALDH1A1, mitochondrial ALDH2, and other isozymes such as ALDH5A1 and ALDH6A1 were oxidatively-modified in rats exposed to alcohol; protein kinases such as protein kinase Cε (PKCε) can phosphorylate and activate mitochondrial ALDH2 - Thr185, Thr412 and possibly Ser279 of ALDH2 could be phosphorylated by PKCε, resulting in ALDH2 activation; ALDH2 could be inhibited through protein nitration based on the recent data where GTN promotes nitration signaling; ALDH2 activity was mildly inhibited by NO or hydrogen peroxide in the experimental conditions, but was markedly inhibited by incubation with peroxynitrite
Bomi215 P04272 Annexin A2 ANXA2 282689 MFGM, Exosome N terminus of AnxA2 contains several major sites for PTMs , including the phosphorylation sites Ser11, Ser25 and Tyr23; human placenta annexin A2 contains potential N-linked glycosylation site at the 61th residue of its amino terminal region
Bomi216 P13214 Annexin A4 ANXA4 281625 MFGM, Exosome phosphorylated by protein kinase C
Bomi218 Q3T0E5 Adipocyte plasma membrane-associated protein APMAP 535740 MFGM, Exosome Asn-196 glycosylated; it contains a putative phosphorylation site at threonine 19
Bomi22 P80209 Cathepsin D CTSD Whey glycoprotein with two N-linked oligosaccharides modified with mannose 6-phosphate residues at asparagine residues 70 and 199
Bomi221 P19035 Apolipoprotein C-III APOC3 408009 MFGM, Exosome Glycosylated: undergoes glycosylation in the Golgi apparatus prior to incorporation in lipoproteins - consists of galactose, N-acetyl-galactosamine, and either zero, one, or two molecules of sialic acid, resulting in three major proteoforms, apoC-III0, apoC-III1, and apoC-III2, respectively
Bomi222 Q3SYR5 Apolipoprotein C-IV APOC4 618041 MFGM, Exosome Glycosylated: As in humans, two major isoforms; one is N -glycosylated, and both are variably sialylated; as found in rabbits, the protein is O-glycosylated with variable sialylation
Bomi223 Q03247 Apolipoprotein E APOE 281004 Whey, MFGM, Exosome Glycosylated: human mature apolipoprotein E (ApoE) is a 299-amino acid glycoprotein (34–37 kDa); various other PTMs include methylation, Dihydroxylation, dimethylation; four glycosylation sites (T194, T289, S290, and S296 residues) on secreted and cellular human ApoE
Bomi224 P84080 ADP-ribosylation factor 1 ARF1 338058 MFGM, Exosome all Arf proteins are myristoylated at the amino terminus-consensus sequence for aminoterminal myristoylation (Metiit-Gly-Xaa-Xaa-Xaa-Ser/Ala/ Thr); Some Arl proteins are myristoylated but most appear to lack this modification
Bomi228 O97902 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 327705 Whey, Exosome Phosphorylated: Phosphorylation by Proline-rich tyrosine kinase 2 at tyrosine 308 and 782
Bomi23 P80457 Xanthine dehydrogenase/oxidase XDH 280960 Whey Bovine XOR is not glycosylated; human XO is N-glycosylated; goat MFGM XO contains sialic acids in O-linked glycosylation
Bomi230 P14568 Argininosuccinate synthase ASS1 280726 Exosome S- nitrosylation
Bomi237 O46382 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 ARFGEF1 281022 Exosome Phosphorylated: Elevation of cell cAMP caused PKA-catalyzed phosphorylation and nuclear accumulation of BIG1; BIG1 and BIG2 contain, respectively, 145 and 140 serines, 112 and 99 threonines, and 42 and 39 tyrosines - potential sites for phosphorylation
Bomi238 P22444 Bone morphogenetic protein 3 BMP3 539527 Whey As found in human kidney, BMP 2 Glycosylated: high-mannose and complex N-linked oligosaccharides; contains five Glycosylated: potential N-linked glycosylation sites (Asn-Xaa-Ser/Thr) at the N135, N163, N164, N200 and N338 positions, four in the prosegment domain and one in the mature region
Bomi239 Q9MZL5 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 327667 MFGM, Exosome Glycosylated: Four potential Nglycosylation sites are present in the rabbit Cav1.2 channel and located in the domain I (N124 and N299) and domain IV (N1359 and N1410)
Bomi24 Q148F1 Cofilin -2 CFL2 539332 Whey Reversible phosphorylation on ser3
Bomi240 Q95323 Carbonic anhydrase 4 CA4 280741 MFGM Glycosylated: Rabbit kidney CA IV had two N-glycosylation sites and was sialated
Bomi241 Q3ZCJ8 Dipeptidyl peptidase 1 CTSC 352958 Whey Glycosylated: four glycans
Bomi244 Q9XSK2 CD63 antigen CD63 404156 Exosome glycosylated: N glycosyated in the extracellular loop
Bomi245 P30932 CD9 antigen CD9 280746 MFGM, Exosome N glycosyated in the extracellular loop; covalently modified by acylation
Bomi247 P35071 Cystic fibrosis transmembrane conductance regulator CFTR 281067 Whey N-glycosylated through addition of two high mannose groups on its fourth extracellular loop
Bomi248 P32749 Cholinesterase BCHE 534616 Whey three potential N-glycosylation sites Asn-265, Asn-350 and Asn-464
Bomi249 Q3SYS6 Calcium-binding protein p22 CHP1 512662 MFGM, Exosome myristoylated
Bomi25 Q28085 Complement factor H CFH 280816 Whey Glycosylation; as found in humans, eight N-glycans; forty disulfide bonds; absence of hybrid and oligomannose structures; presence of complex, diantennary disialylated, non-fucosylated glycans; Disialylated fucosylated and monosialylated non-fucosylated oligosaccharides were also identified; Asn511, Asn700, Asn784, Asn804, Asn864, Asn893, Asn1011 and Asn1077 are glycosylated essentially by diantennary disialylated structures with a relative; absence of hybrid and oligomannose structures
Bomi251 Q765N9 Claudin-3 CLDN3 404153 Exosome protein kinase A in claudin-3 (Thr192, human)
Bomi252 P06623 2',3'-cyclic-nucleotide 3'-phosphodiesterase CNP 280752 Whey, MFGM isoprenoid derived from meva- Ionic acid; only the smaller of the two CNP isoforms (CNP1) is isoprenylated; C-terminal Cys-Thr- Ile-Ile (conserved in rat, mouse, bovine, and human CNP)
Bomi255 P00423 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 281090 MFGM phoshorylated
Bomi257 P81282 Versican core protein VCAN 282662 MFGM, Exosome Glycosylated: As found in porcine, human and mouse,18 potential N-glycosylation sites; 22 potential O-glycosylation sites
Bomi262 Q3SYS4 Dynein assembly factor 1, axonemal DNAAF1 523187 Exosome tubulin glutamylation
Bomi263 O18738 Dystroglycan DAG1 281439 Whey heterodimeric glycoprotein- undergoes N-linked and extensive O-linked glycosylation; contains a large mucin-like domain with a number of Ser or Thr residues, which are potential sites for O-glycosylation; Dystroglycan also contains four potential N-linked glycosylation sites, three in -dystroglycan and one in Glycosylated: -dystroglycan ; The O-linked glycoconjugates contain a fairly unique sugar linkage where mannose is directly coupled to serine or threonine in the dystroglycan peptide
Bomi264 A6H7G2 Drebrin-like protein DBNL 514706 Exosome Phosphorylated: ATM-dependent phosphorylation of DBN at serine-647
Bomi265 Q0III3 Cytoplasmic dynein 1 intermediate chain 2 DYNC1I2 526329 Exosome Phosphorylated: multiple variants generated by differential phosphorylation
Bomi27 Q2KJ32 Selenium-binding protein 1 SELENBP1 510154 Whey tyrosine phosphorylated
Bomi272 P31039 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 281480 Whey, Exosome phosphorylated and acetylated
Bomi279 Q17QN6 55 kDa erythrocyte membrane protein MPP1 510998 Exosome Palmitoylation - four cysteine residues in p55, including one in the SH-3 motif, that may provide potential sites for palmitoylation
Bomi28 Q2TA29 Ras-related protein Rab-11A RAB11A 534708 Whey Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi284 F1MW13 Deoxyribonuclease (Fragment) DNASE1L1 MFGM, Exosome Glycosylated: In humans, N-linked glycosylation at Asn-243- conserved in the corresponding regions of monkey, porcine and bovine DNase X proteins
Bomi286 P00741 Coagulation factor IX (Fragment) F9 Whey Glycosylated: contains approximately 26% carbohydrate which includes 10.6% hexose, 6.5% V-acetylhexosamine, and 8.7% V-acetyIncuraminic acid;
Bomi288 Q5E9P9 Serine hydroxymethyltransferase, cytosolic SHMT1 509002 Whey Ubiquitinated at the small ubiquitin-like modifier (SUMO) consensus motif ; SUMO-1 modification occurs at either Lys-38 or Lys-39
Bomi289 P27674 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 282356 Exosome Glycosylated: M1 and M2 and contains a potential site for asparagine-linked gloycosylation (Asn-Xaa- Thr/Ser; Fig. 2)
Bomi29 Q2TBX4 Heat shock 70 kDa protein HSPA13 505907 Whey O glycosylation was found in HSP6, a member of HSP 70 family; presence of N-acetyl glucosamine
Bomi293 Q3T149 Heat shock protein beta-1 HSPB1 516099 MFGM, Exosome phosphorylated, especially under stress conditions - phosphorylation of serines(S), S15, S78, and S82 in human Hsp27;
Bomi295 O02741 Ubiquitin-like protein ISG15 ISG15 281871 MFGM UCRP is synthesized as precursors that undergo co- or posttranslational processing to yield identical carboxyl-terminal sequences of Leu-Arg-Leu-Arg-Gly-Gly
Bomi297 P00515 cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A 100139910 Exosome Phosphoryaletd: linker regions contain multiple phosphorylation sites including an autophosphorylation site; site for ubiquitination; phosphorylatable Ser in their consensus recognition sequence, and this site is autophosphorylated in the holoenzyme complex
Bomi2973 E1BHI7 Butyrophilin subfamily 1 member A1 BTN1A1 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi301 Q2KIW9 UMP-CMP kinase CMPK1 509965 Exosome Phosphorylated: several putative kinase phosphorylation sites in the UMP/CMPK protein sequence; protein kinase A, but not casein kinase II and protein kinase C, could phosphorylate the UMP/CMPK protein in vitro
Bomi302 P11151 Lipoprotein lipase LPL 280843 Whey, MFGM, Exosome Glycosylated: As found in bovine milk - 10 cysteine residues which are in disulfide bridges. Disulfide bonds are formed between Cys29 and Cys42, CYS 218 and Cys241,C266 and Cys285, C,YS277and Cys280",a nd Cys420 and CYS 440; residues Asn44 and 361 and were identified as potential N-glycosylation sites in bLPL
Bomi303 P27479 Arachidonate 12-lipoxygenase, 12S-type ALOX15 282139 MFGM, Exosome No major PTMs; elements of post-translational regulation are nitric oxide and calcium
Bomi304 A4IF97 Myosin regulatory light chain 12B MYL12B 614055 MFGM, Exosome As found in cow's mammary gland, this protein is phosphorylated by PKC, cofactor 1-Oleoyl-2-acetyl-sn-glycerol, phosphotidyl serine and Ca2+; Phosphorylation of myosin light chains from heart is studied in humans and rats; tyrosine nitration has been implicated in many pathological conditions and diseases such as inflammation, chronic hypoxia, myocardial infarction and diabetes; in chicken gizzard phosphorylation of this protein is done by PS and Ca2+
Bomi309 A6BMK7 Sialidase-1 NEU1 MFGM NEU1- N-terminal N-glycosylated
Bomi3090 F1MZQ4 Butyrophilin subfamily 1 member A1 BTN1A1 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi31 Q3SZV7 Hemopexin HPX 534509 Whey Glycosylated; N-linked glycosylation; mannose, galactose, sialic acids, glucosamine as found in serum hemopexin; virtual blocking of the amino terminus by a galactosamine oligosaccharide, presence of five attachment sites for glucosamine oligosaccharides, and four unusual clusters of tryptophan residues as found in humans
Bomi310 Q27960 Sodium-dependent phosphate transport protein 2B SLC34A2 282484 Whey, MFGM, Exosome Glycosylated:possible sites for N-glycosylation and phosphorylation by protein kinase C as found in bovine renal epithelial cells;
Bomi313 P21793 decorin DCN 280760 Exosome covalent linkage of GAG chains; specifically, the addition of a single chondroitin or dermatan sulfate side chain on a serine residue on the N-terminal side of decorin
Bomi316 Q3T0W4 Protein phosphatase 1 regulatory subunit 7 PPP1R7 505297 Exosome phosphorylated - catalytic subunit of protein phosphatase 2A(PP2Ac) is phosphorylated by receptor and Src family tyrosine kinases on Tyr307,upstream of its carboxyl terminus (Leu309); In vitro, PP2Ac phosphorylation is found to be on Thr residue(s) catalyzed by the autophosphorylation-activated protein kinas ; PP2Ac is methylated on Leu309 by a novel type of carboxyl protein methyltransferase
Bomi317 P09487 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 280994 Whey, MFGM, Exosome glycosylated
Bomi32 Q58D62 Fetuin FETUB 504615 Whey complex triantennary oligosaccharides; possesses considerable N-glycosylation site heterogeneity; asialo-fetuin contains two variant triantennary oligosaccharides with either Galß(l - 3)^3 or Galß(1 - 4) at one of the terminal branch positions; presence of sialylation heterogeneity among each of these oligosaccharides; contains 12 cysteines and makes 6 disulfide bonds
Bomi322 Q08DW0 CD47 molecule CD47 282661 MFGM, Exosome Glycosylated: homotrimeric glycoprotein;IgV domain is N-glycosylated and modified with an O-linked glycosaminoglycan
Bomi323 Q08E01 Adducin 3 (Gamma) ADD3 505225 Exosome Ser-726 and Ser-713 in the C-terminal MARCKS-related domains of α- and β-adducin, respectively, were identified as the major phosphorylation sites common for PKA and PKC
Bomi327 Q2KIW2 CD68 molecule CD68 504960 MFGM Glycosylated:As in mouse macrophage and similar to CD68- heavily glycosylated; nine potential N-linked glycosylation sites and numerous potential 0-linked glycosylation sites; approximately 40% from 0-linked and 20-25% from N-linked sugars, with only about one third coming from the polypeptide backbone
Bomi329 Q2NL04 TAP binding protein (Tapasin) TAPBP 504335 MFGM glycosylated
Bomi330 Q32PK0 Spleen tyrosine kinase SYK 515515 Exosome Phosphorylated: As found in porcine spleen, had autophosphorylation activity
Bomi331 Q3SYR8 Immunoglobulin J chain JCHAIN 280821 Whey, MFGM, Exosome glycoprotein; N linked glycosylation at 39th aa in both bovine and humans; contains eight cysteine residues: two (cys15 and cys69) are involved in disulfide bridges with the α or µ chains; and six are involved in intrachain disulfide bridges
Bomi338 Q9TTF5 CD38 molecule CD38 327677 Exosome Glycosylated: potential N-linked glycosylation sites asparagine residues, N100, N164, N209 and N219
Bomi34 P68250 14-3-3 protein beta/alpha YWHAB 286863 Exosome Phosphorylation of 14-3-3 appears to modulate the function of 14-3-3 isoforms. Three phosphorylation sites have been determined in 14-3-3eta: S58, S184, and T232; in mammalian isoforms, only 14-3-3sigma and 14-3-3eta have a phosphorylation site at the corresponding 232 position
Bomi340 Q58DS5 Ras-related protein Rab-13 RAB13 514541 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi341 A4FV54 Ras-related protein Rab-8A RAB8A 100125881 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi343 A6QNW6 Testis anion transporter 1 SLC26A8 530509 Exosome Glycoysltaed: As found in rats, four putative N-glycosylation sites in the major predicted external loop
Bomi344 Q3MHL4 Adenosylhomocysteinase AHCY 508158 MFGM, Exosome acetylated on two lysines- Lys401 and Lys408
Bomi345 Q0VCA5 SAM domain and HD domain-containing protein 1 SAMHD1 524683 MFGM Phosphoryalted: isoform 1 (iso1) has a phosphorylation site at residue T634
Bomi348 P67810 Signal peptidase complex catalytic subunit SEC11A SEC11A 282078 MFGM glycosylated
Bomi350 Q58DD4 Syndecan-2 SDC2 615785 Exosome phosphorylated - syndecan-2 cytoplasmic domain by the tyrosine kinase receptor EphB;
Bomi351 Q5EA85 Semaphorin-4A SEMA4A 510239 Whey Glycosylated: consensus N-linked glycosylation sites a found in semaphorin 3F in the human nervous system
Bomi354 Q0IIE2 SHC-transforming protein 1 SHC1 507196 Exosome Shc proteins can be phosphorylated by tyrosine kinases on certain conserved tyrosine residues contained within the CH1 region
Bomi359 A0JNJ3 Spartin SPART 534027 Whey, MFGM spartin is constitutively monoubiquitinated and binds to ubiquitin
Bomi36 A0JN55 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 PFKFB3 407183 MFGM phosphoryalted - phosphorylated in the presence of MgATP and cyclic AMP-dependent protein kinasc (PKA) or protein kinasc C (PKC); In rat liver PFK-YFBPase-2, phosphorylation site for PKA lies in the N-terminal domain at Ser-32, for bovine heart PFK-2/FBPase-2 the phosphorylation sites for PKA and PKC are in the C-terminal domain at Ser-466 and Thr-47S, respectively
Bomi361 P98167 SCO-spondin SSPO 282659 Exosome Glycosylated: potent N-linked glycosylation sites
Bomi363 Q3ZBZ8 Stress-induced-phosphoprotein 1 STIP1 617109 Exosome phosphorylated: by casein kinase II and cell division cycle 2 kinase
Bomi369 Q2KJE0 Tax1-binding protein 1 homolog TAX1BP1 535589 Exosome phosphorylated at SKICH domain
Bomi37 A2VE46 Chloride intracellular channel 2 CLIC2 532777 Exosome myristoylation, glycosylation and phosphorylation present either near the transmembrane domain or in the C-terminus
Bomi370 Q9GLM4 Tensin-1 TNS1 286798 Whey, MFGM extensively phosphorylated at tyrosine and serine/threonine sites in response to integrin activation by the extracellular matrix
Bomi38 A7MBG8 RUVBL1 protein RUVBL1 511475 Exosome phosphorylate RUVBL1 by PLK1- T239 site of phosphorylation in vitro
Bomi382 Q2TA49 Vasodilator-stimulated phosphoprotein VASP 514902 Exosome phosphorylated- phosphorylation of VASP is dynamically regulated by cellular adhesion to extracellular matrix; 3 principal phosphorylation sites in VASP, Ser157, Ser239, and Thr278
Bomi41 P46193 Annexin A1 ANXA1 327662 MFGM, Exosome phosphorylated by pkc as found in bocine mammary gland; glycosylated as found in human placenta - presence of N-acetyl-D-galactosamine residues, two cc-linked biantennary mannosyl residues, one site of asparagine-linked glycosylation which may contain two a-linked biantennary mannosyl residues; indicates a potential Nlinked glycosylation site at the 42nd position of its amino terminal region
Bomi44 Q3T0C6 Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 532844 MFGM ß domain has domain has three, eight, and two glycosylation sites in beta1, 2, and 3, respectively
Bomi46 Q95126 Activin receptor type-2B ACVR2B 282131 Exosome ActRIIB.Fc protein contains three potential N-glycosylation sites - two in the extracellular domain of ActRIIB and one in the Fc portion of the fusion molecule
Bomi48 Q27970 Calpain-1 catalytic subunit CAPN1 281661 MFGM, Exosome Phosphorylation - nine phosphorylated residues were identified in calpain 1
Bomi49 Q08DY9 Caspase 3 CASP3 408016 Exosome phosphorylation at the highly conserved position S150; PKCd phosphorylates caspase-3 at S26; DEVD phosphorylates at the +3 (P3) position
Bomi5 P01030 Complement C4 C4 Whey Glycosylated: 4 N linked glycosylation site; α and ß-chains are glycosylated, but no accurate assessment of carbohydrate content in the γ-chain has been reported; C4 in human plasma contains mannose, galactose, glucosamine and sialic acid; contain complex biantennary glycans with varying degrees of sialylation; Human C4A recovered from cerebrospinal fluid was identified to contain an O-linked core 1 glycan; sulfation of three tyrosine residues
Bomi50 P04973 Clathrin light chain A CLTA 281078 Exosome clathrin coated vescilces are phosphorylated in the following places: subunit, AP2 - S ß1 subunit, API - S ß2 subunit, AP2 - S µ1 of AP 1 - S/ T µ2 of AP2 - S (T) LCa - S LCb - S Clathrin heavy chain - Y S
Bomi51 Q27954 Coatomer subunit alpha COPA 100126041 MFGM, Exosome As observed in rat liver, ß and δ-COP are phosphorylated
Bomi52 Q92176 Coronin 1C CORO1A 282196 MFGM, Exosome predicted phosphorylation site at Ser463
Bomi55 Q8HYR6 Dehydrogenase/reductase SDR family member 9 DHRS9 282851 MFGM No glycosylation motif
Bomi58 F1MKZ5 40S ribosomal protein S6 Exosome Phosphorylation of RP S6 - Near its C-terminus, RP S6 has five serine residues (positions 235, 236, 240, 244 and 247) that are phosphorylated in a precise order on the protein integrated in the 40S subunit; N-terminal acetylation and methylation
Bomi60 P48644 Retinal dehydrogenase ALDH1A1 281615 Exosome Glycosylated; 5 N-linked glycans; mixtures of high mannose, complex and hybrid type; 59 different structures have been identified till date; fucosylated and sialylated; presence of unusual motifs including N,N'-diacetyllactosamine as found in bovine milk
Bomi601 P17690 Beta-2-glycoprotein 1 APOH 281006 Whey, Exosome 19% (w/w) carbohydrates attached to N-linked glycosylation sites
Bomi646 P02668 Kappa-casein CSN3 281728 Whey, MFGM, Exosome 2.14% sialic acid
Bomi7 P06394 Keratin, type I cytoskeletal 10 KRT10 281888 Whey undergo several posttranslational modifications (PTMs), including phosphorylation, O-linked glycosylation, ubiquitination, acetylation, SUMOylation, and transamidation; known keratin phosphorylation sites are serine/threonine residues that are located in the head and tail domains of the keratins; glycosylation of keratins also occurs on serine residues
Bomi72 Q5E947 Peroxiredoxin-1 PRDX1 MFGM, Exosome phosphorylation of mammalian PrxI, PrxII, PrxIII and PrxIV at the conserved residue Thr89 (PrxII numbering) by cyclin-dependent kinases ;lipid raft associated prx1 undergoes phosphorylation at Tyr194; centrosomeassociated PrxI through phosphorylation at Thr9;
Bomi73 P56701 26S proteasome non-ATPase regulatory subunit 2 PSMD2 539784 Exosome Post translational modification of 26S proteasome has been studied in yeast - phosphorylation, ubiquitination, SUMOylation, N(α)-Myristoylation, Glutathionylation, Succinylation
Bomi75 Q0VCZ8 Acyl-CoA synthetase long-chain family member 1 ACSL1 537161 MFGM, Exosome As found in liver and brown adipose tissue of mice, universal Nterminal acetylation, 15 acetylated lysines, and 25 phosphorylation sites on ACSL1 was identified
Bomi76 Q1RMR8 RTN4 protein RTN4 359718 MFGM, Exosome As found in Reticulon Protein-1C lysine present in this H4 histone consensus sequence can be acetylated
Bomi78 Q0IIG8 Ras-related protein Rab-18 RAB18 511160 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi79 P62833 Ras-related protein Rap-1A RAP1A 282031 Exosome covalent addition of an isoprenoid group; addition of isoprenyl group to the cysteine residue of the CAAX motif via a thioether linkage; RaplA, ending in CLLL, modified by a geranylgeranyl group at Cys-181; Carboxylmethylation of RaplB and RaplA is stimulated by guanosine 5'-[ɣthio] triphosphate (GTPɣS); substrates for phosphorylation by cyclic AMP-dependent protein kinase; as shown in HL60 which has been differentiated into neutrophil like ceel, rap1A phosphorylation site is Ser-180;
Bomi8 P06868 Plasminogen PLG 280897 Whey N-glycosylated; asparagine residue in position 289
Bomi82 Q5EA77 Sorting nexin-17 SNX17 529972 Exosome serine/threonine phosphorylation
Bomi83 Q3MHR5 Serine/arginine-rich splicing factor 2 SRSF2 508312 MFGM RS domains of SR proteins are extensively phosphorylated by two families of kinases, the SR protein-specific kinases (SRPKs) and Clk/Sty protein kinases; methylation and ubiquitination are also predicted to occur in disordered protein regions
Bomi84 Q0VCI2 Syntaxin-19 STX19 514487 MFGM, Exosome As found in bovine sperm, syntaxin-1 was phosphorylated by casein kinase II on both serine and threonine residues
Bomi86 Q3ZBH0 T-complex protein 1 subunit beta CCT2 505313 Exosome CCT subunits have no bulky post-translational modifications
Bomi88 Q3ZCF7 Ubiquitin-conjugating enzyme E2 D3 UBE2D3 326583 Exosome Ubiquitylation on lysine residues; sumolylation
Bomi9 P07688 Cathepsin B CTSB 281105 Whey 111th Asn is glycosylated with high mannose type sugar
Bomi90 P45879 Voltage-dependent anion-selective channel protein 1 VDAC1 282119 MFGM Glycosylation (O-GlcNAc) of VDAC2 has been shown in mouse embryonic fibroblasts; other post translational modification like Hypernitrosylation and phosphorylation in diseased conditions
Bomi93 A2VDK6 Wiskott-Aldrich syndrome protein family member 2 WASF2 504482 Exosome WASP is constitutively phosphorylated by caseine kinase 2 at the junction of the C and A domains of the VCA module
Bomi94 P06579 Thrombomodulin THBD Whey As studied in modified human urinary thrombomodulin- N-linked oligosaccharides were assigned to Asn29, Asn98, Asn364, Asn391; those structures were estimated biantennary, 2-6 branched triantennary and 2-4 branched triantennary complex type oligosaccharides that were linked by fucose; attachment site of the GAG chain was assigned to Ser472; GAG chain contained chondroitin-4-sulfate and dermatan sulfate, which were repeated approximately 30 times
Bomi95 F6QVC9 Annexin OS ANXA5 Whey Phosphorylated; phosphorylation sites are unique NH2-terminal domains
Bomi98 P00711 Alpha-lactalbumin LALBA 281894 Whey A small percentage of the LA found in the milk of cattle is glycosylated on an Asn residue; presence of neutral sugars such as mannose, galactose and fucose, aminosugars such as glucosamine and galactosamine, presence of N-Acetylneuraminic acid and N-Glyeolloylneuraminic acid