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Database of bovine milk proteins

Protein Gene
Bomi105 P02666 Beta-casein CSN2 Whey Phosphorylated; presence of 5 phosphates in bovine; site of phosphorylation: Ser-Xxx-Glu/pSer; of 12 genetic variants of β -casein in bovine only two variants appear to have altered phosphorylation; Equine β -casein shows variation in phosphorylation, with typically 3 to 7 phosphates on full-length β -casein; the β -casein of human milk exists as six different forms with 0 to 5 phosphates; Ovine β -casein has variable phosphorylation, with 0 to 7 phosphates
Bomi124 P48616 Vimentin VIM 280955 Whey Sumoylation by ubc9; glycosylation by OGT, O-linked β-N-acetylglucosamine; ADP ribosylation by ADP-ribosyl transferase SpyA; numerous phosphorylation sites
Bomi138 Q0VCX2 78 kDa glucose-regulated protein HSPA5 415113 Whey mammalian BiP exists in interconvertible monomeric and oligomeric forms and can be post-translationally modified by phosphorylation and by ADP ribosylation
Bomi157 Q5E9F7 Cofilin -1 CFL1 534553 Whey Cofilin oxidation leads to formation of intramolecular disulfide bonds and to dephosphorylation at Ser3 ; phosphorylation at Ser3 for role in actin filament dynamics
Bomi17 P31976 Ezrin EZR 281574 Whey Phosphorylated; C-terminal threonine phosphorylation
Bomi176 A4IFC8 DNA ligase LIG1 100124507 Exosome at least three potential phosphorylation sites for CKII; Two of these are located in the N-terminal region of the enzyme outside the catalytic domain, whereas the third occurs within an evolutionarily conserved region just over a hundred amino acid residues from the C-terminus of the enzyme
Bomi177 A4IFN6 SNX18 protein SNX18 538366 Exosome serine/threonine phosphorylation
Bomi180 A5PJQ1 DEK protein DEK 540945 MFGM phosphoprotein- several phosphorylation sites of which most are clustered in the carboxy-terminal region- phosphorylation, mediated by CK2 kinase
Bomi186 A6H7D4 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta) AGPAT6 511614 MFGM, Exosome in humans, predicted N-glycosylation site (Asn-59) and O-glycosylation sites (Thr- 233, Thr-262; predicted protein kinase phosphorylation sites (Thr-174)
Bomi215 P04272 Annexin A2 ANXA2 282689 MFGM, Exosome N terminus of AnxA2 contains several major sites for PTMs , including the phosphorylation sites Ser11, Ser25 and Tyr23; human placenta annexin A2 contains potential N-linked glycosylation site at the 61th residue of its amino terminal region
Bomi218 Q3T0E5 Adipocyte plasma membrane-associated protein APMAP 535740 MFGM, Exosome Asn-196 glycosylated; it contains a putative phosphorylation site at threonine 19
Bomi228 O97902 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 327705 Whey, Exosome Phosphorylated: Phosphorylation by Proline-rich tyrosine kinase 2 at tyrosine 308 and 782
Bomi237 O46382 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 ARFGEF1 281022 Exosome Phosphorylated: Elevation of cell cAMP caused PKA-catalyzed phosphorylation and nuclear accumulation of BIG1; BIG1 and BIG2 contain, respectively, 145 and 140 serines, 112 and 99 threonines, and 42 and 39 tyrosines - potential sites for phosphorylation
Bomi24 Q148F1 Cofilin -2 CFL2 539332 Whey Reversible phosphorylation on ser3
Bomi264 A6H7G2 Drebrin-like protein DBNL 514706 Exosome Phosphorylated: ATM-dependent phosphorylation of DBN at serine-647
Bomi265 Q0III3 Cytoplasmic dynein 1 intermediate chain 2 DYNC1I2 526329 Exosome Phosphorylated: multiple variants generated by differential phosphorylation
Bomi293 Q3T149 Heat shock protein beta-1 HSPB1 516099 MFGM, Exosome phosphorylated, especially under stress conditions - phosphorylation of serines(S), S15, S78, and S82 in human Hsp27;
Bomi297 P00515 cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A 100139910 Exosome Phosphoryaletd: linker regions contain multiple phosphorylation sites including an autophosphorylation site; site for ubiquitination; phosphorylatable Ser in their consensus recognition sequence, and this site is autophosphorylated in the holoenzyme complex
Bomi301 Q2KIW9 UMP-CMP kinase CMPK1 509965 Exosome Phosphorylated: several putative kinase phosphorylation sites in the UMP/CMPK protein sequence; protein kinase A, but not casein kinase II and protein kinase C, could phosphorylate the UMP/CMPK protein in vitro
Bomi304 A4IF97 Myosin regulatory light chain 12B MYL12B 614055 MFGM, Exosome As found in cow's mammary gland, this protein is phosphorylated by PKC, cofactor 1-Oleoyl-2-acetyl-sn-glycerol, phosphotidyl serine and Ca2+; Phosphorylation of myosin light chains from heart is studied in humans and rats; tyrosine nitration has been implicated in many pathological conditions and diseases such as inflammation, chronic hypoxia, myocardial infarction and diabetes; in chicken gizzard phosphorylation of this protein is done by PS and Ca2+
Bomi310 Q27960 Sodium-dependent phosphate transport protein 2B SLC34A2 282484 Whey, MFGM, Exosome Glycosylated:possible sites for N-glycosylation and phosphorylation by protein kinase C as found in bovine renal epithelial cells;
Bomi316 Q3T0W4 Protein phosphatase 1 regulatory subunit 7 PPP1R7 505297 Exosome phosphorylated - catalytic subunit of protein phosphatase 2A(PP2Ac) is phosphorylated by receptor and Src family tyrosine kinases on Tyr307,upstream of its carboxyl terminus (Leu309); In vitro, PP2Ac phosphorylation is found to be on Thr residue(s) catalyzed by the autophosphorylation-activated protein kinas ; PP2Ac is methylated on Leu309 by a novel type of carboxyl protein methyltransferase
Bomi323 Q08E01 Adducin 3 (Gamma) ADD3 505225 Exosome Ser-726 and Ser-713 in the C-terminal MARCKS-related domains of α- and β-adducin, respectively, were identified as the major phosphorylation sites common for PKA and PKC
Bomi330 Q32PK0 Spleen tyrosine kinase SYK 515515 Exosome Phosphorylated: As found in porcine spleen, had autophosphorylation activity
Bomi34 P68250 14-3-3 protein beta/alpha YWHAB 286863 Exosome Phosphorylation of 14-3-3 appears to modulate the function of 14-3-3 isoforms. Three phosphorylation sites have been determined in 14-3-3eta: S58, S184, and T232; in mammalian isoforms, only 14-3-3sigma and 14-3-3eta have a phosphorylation site at the corresponding 232 position
Bomi345 Q0VCA5 SAM domain and HD domain-containing protein 1 SAMHD1 524683 MFGM Phosphoryalted: isoform 1 (iso1) has a phosphorylation site at residue T634
Bomi36 A0JN55 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 PFKFB3 407183 MFGM phosphoryalted - phosphorylated in the presence of MgATP and cyclic AMP-dependent protein kinasc (PKA) or protein kinasc C (PKC); In rat liver PFK-YFBPase-2, phosphorylation site for PKA lies in the N-terminal domain at Ser-32, for bovine heart PFK-2/FBPase-2 the phosphorylation sites for PKA and PKC are in the C-terminal domain at Ser-466 and Thr-47S, respectively
Bomi37 A2VE46 Chloride intracellular channel 2 CLIC2 532777 Exosome myristoylation, glycosylation and phosphorylation present either near the transmembrane domain or in the C-terminus
Bomi38 A7MBG8 RUVBL1 protein RUVBL1 511475 Exosome phosphorylate RUVBL1 by PLK1- T239 site of phosphorylation in vitro
Bomi382 Q2TA49 Vasodilator-stimulated phosphoprotein VASP 514902 Exosome phosphorylated- phosphorylation of VASP is dynamically regulated by cellular adhesion to extracellular matrix; 3 principal phosphorylation sites in VASP, Ser157, Ser239, and Thr278
Bomi48 Q27970 Calpain-1 catalytic subunit CAPN1 281661 MFGM, Exosome Phosphorylation - nine phosphorylated residues were identified in calpain 1
Bomi49 Q08DY9 Caspase 3 CASP3 408016 Exosome phosphorylation at the highly conserved position S150; PKCd phosphorylates caspase-3 at S26; DEVD phosphorylates at the +3 (P3) position
Bomi52 Q92176 Coronin 1C CORO1A 282196 MFGM, Exosome predicted phosphorylation site at Ser463
Bomi58 F1MKZ5 40S ribosomal protein S6 Exosome Phosphorylation of RP S6 - Near its C-terminus, RP S6 has five serine residues (positions 235, 236, 240, 244 and 247) that are phosphorylated in a precise order on the protein integrated in the 40S subunit; N-terminal acetylation and methylation
Bomi7 P06394 Keratin, type I cytoskeletal 10 KRT10 281888 Whey undergo several posttranslational modifications (PTMs), including phosphorylation, O-linked glycosylation, ubiquitination, acetylation, SUMOylation, and transamidation; known keratin phosphorylation sites are serine/threonine residues that are located in the head and tail domains of the keratins; glycosylation of keratins also occurs on serine residues
Bomi72 Q5E947 Peroxiredoxin-1 PRDX1 MFGM, Exosome phosphorylation of mammalian PrxI, PrxII, PrxIII and PrxIV at the conserved residue Thr89 (PrxII numbering) by cyclin-dependent kinases ;lipid raft associated prx1 undergoes phosphorylation at Tyr194; centrosomeassociated PrxI through phosphorylation at Thr9;
Bomi73 P56701 26S proteasome non-ATPase regulatory subunit 2 PSMD2 539784 Exosome Post translational modification of 26S proteasome has been studied in yeast - phosphorylation, ubiquitination, SUMOylation, N(α)-Myristoylation, Glutathionylation, Succinylation
Bomi75 Q0VCZ8 Acyl-CoA synthetase long-chain family member 1 ACSL1 537161 MFGM, Exosome As found in liver and brown adipose tissue of mice, universal Nterminal acetylation, 15 acetylated lysines, and 25 phosphorylation sites on ACSL1 was identified
Bomi79 P62833 Ras-related protein Rap-1A RAP1A 282031 Exosome covalent addition of an isoprenoid group; addition of isoprenyl group to the cysteine residue of the CAAX motif via a thioether linkage; RaplA, ending in CLLL, modified by a geranylgeranyl group at Cys-181; Carboxylmethylation of RaplB and RaplA is stimulated by guanosine 5'-[ɣthio] triphosphate (GTPɣS); substrates for phosphorylation by cyclic AMP-dependent protein kinase; as shown in HL60 which has been differentiated into neutrophil like ceel, rap1A phosphorylation site is Ser-180;
Bomi82 Q5EA77 Sorting nexin-17 SNX17 529972 Exosome serine/threonine phosphorylation
Bomi90 P45879 Voltage-dependent anion-selective channel protein 1 VDAC1 282119 MFGM Glycosylation (O-GlcNAc) of VDAC2 has been shown in mouse embryonic fibroblasts; other post translational modification like Hypernitrosylation and phosphorylation in diseased conditions
Bomi95 F6QVC9 Annexin OS ANXA5 Whey Phosphorylated; phosphorylation sites are unique NH2-terminal domains