Browse BoMiProt


Database of bovine milk proteins

BoMiProt
Id.
Uniprot
ID
Protein Gene
Name
Gene
ID
Milk
Fraction
PTMs
Bomi101 P01044 Kininogen-1 KNG1 280833 Whey Bovine fragment 1.2 of HMW kininogen has four oligosaccharide chains that attached to serine and threonine residues. The residues with oligosaccharide chains are S10, T10, T12, S18 from the amino-terminal of the fragment 1.2;
Bomi102 P01888 Beta-2-microglobulin B2M 280729 Whey incubating normal ß2M with glucose produces advanced glycatione end products that make ß2M more acidic- promotes amyloidosis
Bomi103 P02662 Alpha-S1-casein CSN1S1 282208 Whey Phosphoprotein; nine phosphorylated serine residues and a highly negatively charged region including residues 41-77
Bomi104 P02663 Alpha-S2-casein CSN1S2 282209 Whey Phosphorylated; 11 phosphorylated serine residues; phosphorylated residues varies from 10 to 13 minor degrees of intermolecular disulfide bonding
Bomi106 P02676 Fibrinogen beta chain FGB Whey Glycosylated; biantennary oligosaccharides; sialic acids vary in the normal subpopulation of fibrinogen polypeptide as found in humans; sialic acids linkage in monosialylated sugars is either on 90% Manα(l -3) side and 10% on the Manα(1-6) side ;
Bomi112 P15497 Apolipoprotein A-I APOA1 281631 Whey Lipoprotein; forty-four residue consensus sequence peptides (ABAB), real sequence peptides, RSP-1 (H4–5) and RSP-2 (H5–H6) were studied in plasma. RSP-1 exhibited higher lipid affinity than RSP-2 in terms of helical structure induced by detergent, suggesting that H4 has higher lipid-binding affinity than H6; little difference was seen in the α-helical content or lipid affinity of the larger vs. the 22-mer peptides, indicating that the individual domains do not fold/bind lipid cooperatively;
Bomi115 P23805 Conglutinin CGN1 281068 Whey presence of O-linked glycans of β(1-3)-GalNAc and α-(2-3) linked sialic acid type. No N-linked glycans were detected
Bomi116 P24627 Lactotransferrin LTF 280846 Whey Glycosylated; 5 N-linked glycans; mixtures of high mannose, complex and hybrid type; 59 different structures have been identified till date; fucosylated and sialylated; presence of unusual motifs including N,N'-diacetyllactosamine as found in bovine milk
Bomi119 P31096 Osteopontin SPP1 281499 Whey Phosphorylated glycoprotein; ~25 phosphates distributed over 36 potential sites in human milk osteopontin; ~22 phosphates distributed over 28 potential sites in bovine milk osteopontin; Bovine milk OPN contains three O-glycosylated threonine residues close to the integrin binding motifs; The glycan structures on human milk OPN have been shown to consist of large fucosylated N-acetyllactosamine units; the carbohydrates on bovine OPN consist of a disialylated GalNAc-galactose cores
Bomi132 P80929 Angiogenin2 ANG2 Whey cross-linked by three disulfide bonds, is glycosylated at Asn33; contained 5 - 6 mannose, 2- 3 glucosamine, 1-2 galactosamine, up to one xylose and no sialic acid residues;
Bomi133 P81187 Complement factor B CFB 514076 Whey Glycosylated; glucose is covalently attached; sialylated complex biantennary sugars
Bomi134 P81265 Polymeric immunoglobulin receptor PIGR 281401 Whey Heavily N-glycosylated; contains glucose, N-acetylglucosamine, N-acetylgalactosamine. and N-acetylneuraminic acid as detected in human colustrum
Bomi136 Q0IIH5 Nucleobindin 2 NUCB2 509003 Whey Phosphorylated as found in gastric mucosa; might be glycosylated
Bomi137 Q0III8 RNASET2 protein (Fragment) RNASET2 508245 Whey glycosylated in eukaryotic cells- glucose, mannose, glucosamine, galactose and xylose
Bomi140 Q28178 Thrombospondin-1 THBS1 281530 Whey Glycosylated; contains neutral sugars, amino sugars, sialic acids;
Bomi141 Q29443 Serotransferrin TF 280705 Whey Glycosylated; carbohydrate content varies from 3 to 11.8% of total protein weight; biantennary structure; presence of branched, hetero N-glycan chains; each glycan consists of two sialic acid, two galactose, three mannose and four N-acetylglucosamine residues;
Bomi142 Q2KIF2 Leucine-rich alpha-2-glycoprotein LRG1 514663 Whey has two intrachain disulfide bonds; one galactosamine and four glucosamine oligosaccharides attached;
Bomi144 Q2KIS7 Tetranectin CLEC3B 515783 Whey contains a long-form carbohydrate recognition domain with three disulfide bridges
Bomi145 Q2KJF1 Alpha-1B-glycoprotein A1BG 518955 Whey single polypeptide chain N-linked to four glucosamine oligosaccharides; All four glucosamine oligosaccharides are attached to asparagine in the obligate tripeptide acceptor sequence Asn-Xaa-Ser/Thr, in which Xaa is almost any amino acid; five intrachain disulfide bonds
Bomi147 Q2UVX4 Complement C3 C3 280677 Whey Glycosylated; N-linked high-mannose carbohydrate moieties are attached at residues 917 of the α-chain and 63 of the ß-chain
Bomi150 Q3SZ57 Alpha-fetoprotein AFP 506011 Whey glycoprotein; bAFP in FBS is approximately evenly divided between Con A reactive and non-reactive variants; bAFP in amniotic fluid from an early gestation animal exhibited 72% reactive and 28% non-reactive variants
Bomi152 Q3SZR3 Alpha-1-acid glycoprotein ORM1 497200 Whey A glycoprotein; carbohydrate moiety accounting for 26.6% of its molecular weight; presence of sialic acid-containing diantennary oligosaccharides which is composed of only N-glycolylneuraminic acid as reported in bovine milk; presence of 2 isoforms in milk, one from mammary galnd and another from somatic cells; isoforms share a similar content of sialic acid a(2-3)- and a(2-6)-linked to galactose; somatic cells produce AGP isoforms that are strongly fucosylated and contain an elevated number of diantennary glycans; in humans the protein has five N-linked glycans; different degrees of branching; structurally heterogeneous due to the great diversity of the terminating sugars;
Bomi153 Q3T004 Serum amyloid P-component APCS 514488 Whey Glycosylated; a single N-linked biantennary oligosaccharide attached to Asn32
Bomi159 Q7SIH1 Alpha-2-macroglobulin A2M 513856 Whey Glycosylayted; 4 identical subunits have 8-N glycosylated sites in each subunit as found in humans;
Bomi161 Q8MI01 Mucin 15 MUC15 337919 Whey Heavily O-glycosylated; glycans are composed of fucose, galactose, mannose, N-acetylgalactosamine, N-acetylglycosamine, and sialic acid; hybrid-type N-glycans - sialylated and contain terminal poly-lactosamine structures; O-linked glycans were found to constitute some unsubstituted Core- 1 structures and a substantial number of sialylated Core-1 O-linked glycans; complex O-glycans contain high amounts N-acetylglucosamine residues and a small subset of is decorated with lactosamine on their terminal ends
Bomi163 Q95114 Lactadherin MFGE8 281913 Whey Glycosylated; contained galactose, N-acetylgalactosamine and fucose, and which was 0- linked to Ser9 in PAS-6 and to Thr16 in PAS-7 as detected in bovine MFG; N and O-glycosylated depending on different isoforms found in mouse mammary gland
Bomi167 Q9TUM6 Perilipin-2 PLIN2 280981 Whey phosphorylated
Bomi184 A5PKL2 RRAS2 protein RRAS2 519269 MFGM, Exosome exhibited increased lysine fatty acylation in mouse embryonic fibroblast and Human Embryonic Kidney
Bomi19 P62157 Calmodulin CALM 617095 Whey Trimethyllysine, which is amino acid residue 115 in beef calmodulin, occurs as the result of posttranslational N-methylation catalyzed by S-adenosylmethionine:calmodulin (lysine) N-methyltransferase; substrate for protein carboxylmethyltransferase; calmodulin converting enzyme clips the carboxyl terminal lysine from calmodulin; undergoes acetylation of its N-terminal amino acid residue (alanine)4
Bomi199 A7Z024 RP2 protein RP2 534054 MFGM, Exosome Contains both myristoylation and palmitoylation sites in its N‐terminal end- As found in humans, Met-Gly-Cys-X-Phe-Ser-Lys N-terminal motif
Bomi203 A8PVV5 SYPL1 protein SYPL1 615728 MFGM acidic glycoprotein
Bomi204 Q4GZT4 ATP-binding cassette sub-family G member 2 ABCG2 536203 MFGM, Exosome intermolecular disulfide bond at position 603
Bomi213 P20000 Aldehyde dehydrogenase, mitochondrial ALDH2 508629 MFGM cytosolic ALDH1A1, mitochondrial ALDH2, and other isozymes such as ALDH5A1 and ALDH6A1 were oxidatively-modified in rats exposed to alcohol; protein kinases such as protein kinase Cε (PKCε) can phosphorylate and activate mitochondrial ALDH2 - Thr185, Thr412 and possibly Ser279 of ALDH2 could be phosphorylated by PKCε, resulting in ALDH2 activation; ALDH2 could be inhibited through protein nitration based on the recent data where GTN promotes nitration signaling; ALDH2 activity was mildly inhibited by NO or hydrogen peroxide in the experimental conditions, but was markedly inhibited by incubation with peroxynitrite
Bomi216 P13214 Annexin A4 ANXA4 281625 MFGM, Exosome phosphorylated by protein kinase C
Bomi22 P80209 Cathepsin D CTSD Whey glycoprotein with two N-linked oligosaccharides modified with mannose 6-phosphate residues at asparagine residues 70 and 199
Bomi222 Q3SYR5 Apolipoprotein C-IV APOC4 618041 MFGM, Exosome Glycosylated: As in humans, two major isoforms; one is N -glycosylated, and both are variably sialylated; as found in rabbits, the protein is O-glycosylated with variable sialylation
Bomi224 P84080 ADP-ribosylation factor 1 ARF1 338058 MFGM, Exosome all Arf proteins are myristoylated at the amino terminus-consensus sequence for aminoterminal myristoylation (Metiit-Gly-Xaa-Xaa-Xaa-Ser/Ala/ Thr); Some Arl proteins are myristoylated but most appear to lack this modification
Bomi230 P14568 Argininosuccinate synthase ASS1 280726 Exosome S- nitrosylation
Bomi241 Q3ZCJ8 Dipeptidyl peptidase 1 CTSC 352958 Whey Glycosylated: four glycans
Bomi244 Q9XSK2 CD63 antigen CD63 404156 Exosome glycosylated: N glycosyated in the extracellular loop
Bomi245 P30932 CD9 antigen CD9 280746 MFGM, Exosome N glycosyated in the extracellular loop; covalently modified by acylation
Bomi247 P35071 Cystic fibrosis transmembrane conductance regulator CFTR 281067 Whey N-glycosylated through addition of two high mannose groups on its fourth extracellular loop
Bomi249 Q3SYS6 Calcium-binding protein p22 CHP1 512662 MFGM, Exosome myristoylated
Bomi251 Q765N9 Claudin-3 CLDN3 404153 Exosome protein kinase A in claudin-3 (Thr192, human)
Bomi252 P06623 2',3'-cyclic-nucleotide 3'-phosphodiesterase CNP 280752 Whey, MFGM isoprenoid derived from meva- Ionic acid; only the smaller of the two CNP isoforms (CNP1) is isoprenylated; C-terminal Cys-Thr- Ile-Ile (conserved in rat, mouse, bovine, and human CNP)
Bomi255 P00423 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 281090 MFGM phoshorylated
Bomi262 Q3SYS4 Dynein assembly factor 1, axonemal DNAAF1 523187 Exosome tubulin glutamylation
Bomi27 Q2KJ32 Selenium-binding protein 1 SELENBP1 510154 Whey tyrosine phosphorylated
Bomi272 P31039 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 281480 Whey, Exosome phosphorylated and acetylated
Bomi279 Q17QN6 55 kDa erythrocyte membrane protein MPP1 510998 Exosome Palmitoylation - four cysteine residues in p55, including one in the SH-3 motif, that may provide potential sites for palmitoylation
Bomi28 Q2TA29 Ras-related protein Rab-11A RAB11A 534708 Whey Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi286 P00741 Coagulation factor IX (Fragment) F9 Whey Glycosylated: contains approximately 26% carbohydrate which includes 10.6% hexose, 6.5% V-acetylhexosamine, and 8.7% V-acetyIncuraminic acid;
Bomi288 Q5E9P9 Serine hydroxymethyltransferase, cytosolic SHMT1 509002 Whey Ubiquitinated at the small ubiquitin-like modifier (SUMO) consensus motif ; SUMO-1 modification occurs at either Lys-38 or Lys-39
Bomi289 P27674 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 282356 Exosome Glycosylated: M1 and M2 and contains a potential site for asparagine-linked gloycosylation (Asn-Xaa- Thr/Ser; Fig. 2)
Bomi295 O02741 Ubiquitin-like protein ISG15 ISG15 281871 MFGM UCRP is synthesized as precursors that undergo co- or posttranslational processing to yield identical carboxyl-terminal sequences of Leu-Arg-Leu-Arg-Gly-Gly
Bomi303 P27479 Arachidonate 12-lipoxygenase, 12S-type ALOX15 282139 MFGM, Exosome No major PTMs; elements of post-translational regulation are nitric oxide and calcium
Bomi309 A6BMK7 Sialidase-1 NEU1 MFGM NEU1- N-terminal N-glycosylated
Bomi313 P21793 decorin DCN 280760 Exosome covalent linkage of GAG chains; specifically, the addition of a single chondroitin or dermatan sulfate side chain on a serine residue on the N-terminal side of decorin
Bomi317 P09487 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 280994 Whey, MFGM, Exosome glycosylated
Bomi322 Q08DW0 CD47 molecule CD47 282661 MFGM, Exosome Glycosylated: homotrimeric glycoprotein;IgV domain is N-glycosylated and modified with an O-linked glycosaminoglycan
Bomi329 Q2NL04 TAP binding protein (Tapasin) TAPBP 504335 MFGM glycosylated
Bomi340 Q58DS5 Ras-related protein Rab-13 RAB13 514541 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi341 A4FV54 Ras-related protein Rab-8A RAB8A 100125881 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi344 Q3MHL4 Adenosylhomocysteinase AHCY 508158 MFGM, Exosome acetylated on two lysines- Lys401 and Lys408
Bomi348 P67810 Signal peptidase complex catalytic subunit SEC11A SEC11A 282078 MFGM glycosylated
Bomi350 Q58DD4 Syndecan-2 SDC2 615785 Exosome phosphorylated - syndecan-2 cytoplasmic domain by the tyrosine kinase receptor EphB;
Bomi354 Q0IIE2 SHC-transforming protein 1 SHC1 507196 Exosome Shc proteins can be phosphorylated by tyrosine kinases on certain conserved tyrosine residues contained within the CH1 region
Bomi359 A0JNJ3 Spartin SPART 534027 Whey, MFGM spartin is constitutively monoubiquitinated and binds to ubiquitin
Bomi363 Q3ZBZ8 Stress-induced-phosphoprotein 1 STIP1 617109 Exosome phosphorylated: by casein kinase II and cell division cycle 2 kinase
Bomi369 Q2KJE0 Tax1-binding protein 1 homolog TAX1BP1 535589 Exosome phosphorylated at SKICH domain
Bomi370 Q9GLM4 Tensin-1 TNS1 286798 Whey, MFGM extensively phosphorylated at tyrosine and serine/threonine sites in response to integrin activation by the extracellular matrix
Bomi50 P04973 Clathrin light chain A CLTA 281078 Exosome clathrin coated vescilces are phosphorylated in the following places: subunit, AP2 - S ß1 subunit, API - S ß2 subunit, AP2 - S µ1 of AP 1 - S/ T µ2 of AP2 - S (T) LCa - S LCb - S Clathrin heavy chain - Y S
Bomi51 Q27954 Coatomer subunit alpha COPA 100126041 MFGM, Exosome As observed in rat liver, ß and δ-COP are phosphorylated
Bomi60 P48644 Retinal dehydrogenase ALDH1A1 281615 Exosome Glycosylated; 5 N-linked glycans; mixtures of high mannose, complex and hybrid type; 59 different structures have been identified till date; fucosylated and sialylated; presence of unusual motifs including N,N'-diacetyllactosamine as found in bovine milk
Bomi646 P02668 Kappa-casein CSN3 281728 Whey, MFGM, Exosome 2.14% sialic acid
Bomi76 Q1RMR8 RTN4 protein RTN4 359718 MFGM, Exosome As found in Reticulon Protein-1C lysine present in this H4 histone consensus sequence can be acetylated
Bomi78 Q0IIG8 Ras-related protein Rab-18 RAB18 511160 MFGM, Exosome Prenylation—addition of one or two geranyl- geranyl groups—on conserved carboxyterminal cysteine residues; mammalian Rab GTPases undergoes adenylation or phosphocholination by bacterial enzymes that can occur on the membrane-bound, inactive Rab and preclude GDI rebinding
Bomi8 P06868 Plasminogen PLG 280897 Whey N-glycosylated; asparagine residue in position 289
Bomi83 Q3MHR5 Serine/arginine-rich splicing factor 2 SRSF2 508312 MFGM RS domains of SR proteins are extensively phosphorylated by two families of kinases, the SR protein-specific kinases (SRPKs) and Clk/Sty protein kinases; methylation and ubiquitination are also predicted to occur in disordered protein regions
Bomi84 Q0VCI2 Syntaxin-19 STX19 514487 MFGM, Exosome As found in bovine sperm, syntaxin-1 was phosphorylated by casein kinase II on both serine and threonine residues
Bomi86 Q3ZBH0 T-complex protein 1 subunit beta CCT2 505313 Exosome CCT subunits have no bulky post-translational modifications
Bomi88 Q3ZCF7 Ubiquitin-conjugating enzyme E2 D3 UBE2D3 326583 Exosome Ubiquitylation on lysine residues; sumolylation
Bomi9 P07688 Cathepsin B CTSB 281105 Whey 111th Asn is glycosylated with high mannose type sugar
Bomi93 A2VDK6 Wiskott-Aldrich syndrome protein family member 2 WASF2 504482 Exosome WASP is constitutively phosphorylated by caseine kinase 2 at the junction of the C and A domains of the VCA module
Bomi94 P06579 Thrombomodulin THBD Whey As studied in modified human urinary thrombomodulin- N-linked oligosaccharides were assigned to Asn29, Asn98, Asn364, Asn391; those structures were estimated biantennary, 2-6 branched triantennary and 2-4 branched triantennary complex type oligosaccharides that were linked by fucose; attachment site of the GAG chain was assigned to Ser472; GAG chain contained chondroitin-4-sulfate and dermatan sulfate, which were repeated approximately 30 times
Bomi98 P00711 Alpha-lactalbumin LALBA 281894 Whey A small percentage of the LA found in the milk of cattle is glycosylated on an Asn residue; presence of neutral sugars such as mannose, galactose and fucose, aminosugars such as glucosamine and galactosamine, presence of N-Acetylneuraminic acid and N-Glyeolloylneuraminic acid