Browse BoMiProt


Database of bovine milk proteins

BoMiProt
Id.
Uniprot
ID
Protein Gene
Name
Gene
ID
Milk
Fraction
PTMs
Bomi1 Q0VCM5 Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 508356 Whey Glycosylated: two potential N-glycosylation sites of H1 are effectively fully occupied by complex-type N-glycans- predominantly of biantennary type; H2 heavy chain carries only one complex-type N-glycan attached to Asn64; O-glycan carried by Thr637, two or three additional O-linked carbohydrate chains are present on H2-consist of a type-1 core structure with one or two NeuAc moieties;
Bomi10 P17697 Clusterin CLU 280750 Whey heavy glycosylation; carbohydrate comprises approximately 20-25% of the total mass of the mature molecule; six N-linked glycosylation sites have been identified, three in the alpha chain (α64N, α81N, and α123N) and three in the beta chain (ß64N, ß127N, and ß147N); types of oligosaccharides attached to the clusterin peptide are diverse;
Bomi100 P01035 Cystatin-C CST3 281102 Whey 2 intracellular disulfide bonds; no glycosylation; chicken cystatin is phosphorylated;
Bomi110 P12763 Alpha-2-HS-glycoprotein AHSG 280988 Whey three potential N-glycosylation sites identified in mouse AHSG are conserved in bovine fetuin, while only two of them are conserved in human AHSG; in humans A-chain of a2HS contains 2 biantennary N- and 2 O-linked glycans; N-glycan has a2-6 NeuAc residues, 4 Gal, αMan, N glycans are partially (~90%) sialylated; O-glycans have partially sialylated 2.5 α2-3-linked NeuAc; 3 0-trisaccharides have the structure NeuAcα2-3Gal01-3GalNAcαl- 0
Bomi113 P18892 Butyrophilin subfamily 1 member A1 BTN1A1 282157 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi121 P34955 Alpha-1-antiproteinase SERPINA1 280699 Whey glycosylation at three distinct asparagine residues; These asparagine-linked side chains are composed of N-acetylglucosamine, mannose, galactose, and sialic acid arranged as a core with two to three branching “antennae”
Bomi123 P42916 Collectin-43 CL43 431784 Whey CL -43 does not posses N-linked carbohydrate, but it contains hydroxylysine residues in the collagen-like region that are potential O-glycosylation sites
Bomi124 P48616 Vimentin VIM 280955 Whey Sumoylation by ubc9; glycosylation by OGT, O-linked β-N-acetylglucosamine; ADP ribosylation by ADP-ribosyl transferase SpyA; numerous phosphorylation sites
Bomi125 P52193 Calreticulin CALR 281036 Whey Depending on species, calreticulin may have one or more potential N-linked glycosylation sites; The glycosylation pattern of the protein seems to be heterogeneous and does not appear to be a conserved property of the protein. The glycosylation of calreticulin is more common in plants than in animal cells; bovine liver calreticulin appears to be glycosylated with two potential N-linked glycosylation sites; carbohydrate composition, GlcNac2Man4 -9 with GlcNAc2Man5 being most abundant in bovine brain calreticulum; rat liver protein is glycosylated with complex hybrid type of oligosaccharide with a terminal galactose residue
Bomi131 P80025 Lactoperoxidase LPO 280844 Whey glycoprotein; four to five N-glycosylation sites and are characterizedby a carbohydrate content of about 10 %;
Bomi139 Q17QK3 Carboxypeptidase Q CPQ 540923 Whey heavily N- and Oglycosylated - ten N-glycosylation sites predicted within the primary sequence of human GCPII
Bomi14 P25326 Cathepsin S CTSS 327711 Whey potential glycosylation sites are located in the propeptide at position Asn104 in the human enzyme; Asn100 as well as Asn110 in the rat enzyme; Human cathepsin S contains three disulfide bonds (Cys136-Cys180, Cys170-Cys213, Cys272-Cys320). Cys139, His278 and Asn298
Bomi146 Q2TBU0 Haptoglobin HP 280692 Whey Acidic glycoprotein tetramer; β-chain contains four N-glycosylation sites at Asn184, Asn207, Asn211 and Asn241; increased O-glycosylation like fucosylation was revealed in different diseases; fucosylation and sialylation have been reported to influence ligand–receptor interactions as found in humans
Bomi148 Q3MHN5 Vitamin D-binding protein GC 530076 Whey Glycosylated; GC1 forms have glycosylations at positions 418 and 420, whereas GC2 has glycosylation only at 418; trisaccharides as most frequent in GC1 with lesser amounts of disaccharides as found in humans
Bomi154 Q3ZBX0 Basigin BSG 508716 Whey Members of CD147 family, EMMPRIN, basigin, 5A11/HT7 from different species, tissues or cells appear as diverse glycosylated forms, with large variation in molecular weight. Basigin in human, mouse and chicken has three Asn glycosylation sites to which high mannose-type and complex-type glycans are linked; High mannose-type glycans are composed of mannose and N-acetylglucosamine, while complextype glycans have outer chains containing sialic acid, galactose and N-acetylglucosamine. Importantly, poly- N-acetyllactosamine (a repeating structure of galactose and N-acetylglucosamine) is present in an outer chain, the so-called b1,6-branch, of BSG glycans; CD147 exhibited both high-mannose type and bi-antennary complex-type oligosaccharides; presence of β1,6-branched oligosaccharides, the sialyl Lewis X structure, namely, Galβ1, 4Fucα1,3GlcNAc, in N-glycans of CD147 ;
Bomi155 Q3ZCH5 Zinc-alpha-2-glycoprotein AZGP1 508800 Whey Glycosylated; typical N-linked biantennary structure,substituted with N-acetylneuraminic acid in a 2,6 linkage and lacks fucose; 4 putative glycosylation sites; Asn 89, 92,106, 239; Asn 89,106, 239 carry glucosamines; Asn 239 is heavilly silalylated on mannose 2,6 arm;
Bomi16 P28800 Alpha-2-antiplasmin SERPINF2 282522 Whey Human α 2-antiplasmin Glycosylated; 11% to 14% carbohydrate (four putative N-linked glycosylation sites at asparagine residues 99, 268, 282, and 289) and a sulfated tyrosine residue at position 457; contains 1 disulfide bridge (between the cysteine residues in positions 43 and 116; 70% of circulating protein is N-terminally cleaved between the proline residue at position 12 and the asparagine residue at position 13; 30% circulatates with a methionine (Met) residue at the N terminus;
Bomi160 Q8MHZ9 Collectin-46 CL46 415114 Whey Potential N-glycosylation site is localized at asparagine 90 in the collagen-like region
Bomi162 Q8WML4 Mucin 1 MUC1 281333 Whey glycoprotein; 50% carbohydrate, 30% of which was sialic acid; polymorphic and carbohydrate portion is of variable nature; serine and threonine hydroxyls provide sites for glycosylation; human milk MUC1 has high galactose, modest level of sialic acid, and lack of detectable mannose; bovine MUC1 has less galactose, significant mannose and much higher sialic acid; galactose and N-acetylglucosamine are the dominant sugars in the human mucin; O-linked oligosaccharides are comprised of a core unit attached to MUCl via N-acetylgalactosamine, a backbone, and a terminal region; The core and backbone may be branched and the ends may be terminated by sialic acid, galactose, fucose or N-acetylgalactosamine; Sulfation may also occur at the periphery;
Bomi164 Q9N2I2 Plasma serine protease inhibitor SERPINA5 338050 Whey single-chain glycoprotein; five putative glycosylation sites: three Asn-X-Ser/Thr sequences and two Thr/Ser-X-X-Pro.
Bomi168 A0JNE0 SPARC related modular calcium binding 1 SMOC1 508379 Exosome three predicted N-glycosylation sites- Asn-153, Asn-214, and Asn-374
Bomi172 A2VDW7 Solute carrier organic anion transporter family, member 1A2 SLCO1A2 282472 Exosome when expressed in HeLa cells, five putative N-glycosylation sites were identified, including Asn residues at the amino acid positions of 62, 124, 412, and 483 as well as the 135 position
Bomi186 A6H7D4 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta) AGPAT6 511614 MFGM, Exosome in humans, predicted N-glycosylation site (Asn-59) and O-glycosylation sites (Thr- 233, Thr-262; predicted protein kinase phosphorylation sites (Thr-174)
Bomi190 A6QNW8 CD97 molecule ADGRE5 MFGM, Exosome contains 8 potential N-glycosylation sites.The first 2 sites are located within the first EGF domain, the thirdsite within the second EGF domain. The other 5 sites are locatedwithin the stalk
Bomi193 A6QQP5 SPN protein SPN 614645 MFGM transmembrane sialoglycoprotein- N-glycan (2) shown in this study to be attached to peptide PaPr-1, which contains Asn-220, the only site in the Galgp and CD43 amino acid sequence with the characteristic tripeptide, Asn-Xaa-(Ser or Thr), leading to N-glycosylation. Peptide PaPr-1 was shown earlier by NMR spectroscopic analysis to possess a fucosylated diantennary glycan (2). N-glycosylation has been demonstrated for human CD43 (6, 17), but the structure of the CD43 N-glycan has not been identified; high density of O-glycans - glycosylation status was defined for 28 of the serine and threonine residues, of which 25 have O-glycans and 3 were shown to be nonglycosylated (Fig. 1). If this glycosylated to nonglycosylated ratio applies throughout the molecule, Galgp, which has 92 serine plus threonine residues, would contain -82 O-glycans. In the case of CD43, estimates based on compositional data (human and rat CD43; refs. 4-6) and peptide sequence (rat CD43; ref. 21) yield values of >75 O-glycans per molecule; 0-glycans, expressing predominantly tetrasaccharides in the case of circulating T lymphocyte and monocyte CD43 and the above hexasaccharide in the case of neutrophil, platelet, and activated T-lymphocyte CD43
Bomi196 A7E3T1 CD151 antigen CD151 523328 Exosome glycosylation sites in EC2 domain
Bomi2 F1MSZ6 Antithrombin-III SERPINC1 Whey Glycosylated: single chain glycoprotein; 4 glycosylation sites in human ATIII. Three of them, Asn96, 155 and 192, have been identified in the bovine ATIII sequence.The secreted human ATIII contains 432 amino acids, 6 of which are cysteines that form 3 disulfide bridges which are conserved in the bovine protein: Cys8-Cys128, Cys21-Cys95, Cys247- Cys430
Bomi209 P46446 Aspartoacylase ASPA Exosome A putative N-glycosylation site (Asn117) contained in an Asn-X-Thr/Ser recognition sequence; located adjacent to one of the proposed histidine metal ion ligands
Bomi2098 Q9MZ06 Fibroblast growth factor-binding protein 1 FGFBP1 281812 Whey, Exosome glycosylation sites revealed the presence of glycans on Asn155 and Ser172
Bomi210 Q10741 Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 282132 Whey, Exosome As found in bovine ADAM 10, four potential N-glycosylation sites (N267, N278, N439 and N551); contain high-mannose and complex-type glycans; three located in the metalloprotease domain (N267, N278 and N439) and one in the disintegrin domain (N551)
Bomi215 P04272 Annexin A2 ANXA2 282689 MFGM, Exosome N terminus of AnxA2 contains several major sites for PTMs , including the phosphorylation sites Ser11, Ser25 and Tyr23; human placenta annexin A2 contains potential N-linked glycosylation site at the 61th residue of its amino terminal region
Bomi221 P19035 Apolipoprotein C-III APOC3 408009 MFGM, Exosome Glycosylated: undergoes glycosylation in the Golgi apparatus prior to incorporation in lipoproteins - consists of galactose, N-acetyl-galactosamine, and either zero, one, or two molecules of sialic acid, resulting in three major proteoforms, apoC-III0, apoC-III1, and apoC-III2, respectively
Bomi223 Q03247 Apolipoprotein E APOE 281004 Whey, MFGM, Exosome Glycosylated: human mature apolipoprotein E (ApoE) is a 299-amino acid glycoprotein (34–37 kDa); various other PTMs include methylation, Dihydroxylation, dimethylation; four glycosylation sites (T194, T289, S290, and S296 residues) on secreted and cellular human ApoE
Bomi23 P80457 Xanthine dehydrogenase/oxidase XDH 280960 Whey Bovine XOR is not glycosylated; human XO is N-glycosylated; goat MFGM XO contains sialic acids in O-linked glycosylation
Bomi238 P22444 Bone morphogenetic protein 3 BMP3 539527 Whey As found in human kidney, BMP 2 Glycosylated: high-mannose and complex N-linked oligosaccharides; contains five Glycosylated: potential N-linked glycosylation sites (Asn-Xaa-Ser/Thr) at the N135, N163, N164, N200 and N338 positions, four in the prosegment domain and one in the mature region
Bomi239 Q9MZL5 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 327667 MFGM, Exosome Glycosylated: Four potential Nglycosylation sites are present in the rabbit Cav1.2 channel and located in the domain I (N124 and N299) and domain IV (N1359 and N1410)
Bomi240 Q95323 Carbonic anhydrase 4 CA4 280741 MFGM Glycosylated: Rabbit kidney CA IV had two N-glycosylation sites and was sialated
Bomi248 P32749 Cholinesterase BCHE 534616 Whey three potential N-glycosylation sites Asn-265, Asn-350 and Asn-464
Bomi25 Q28085 Complement factor H CFH 280816 Whey Glycosylation; as found in humans, eight N-glycans; forty disulfide bonds; absence of hybrid and oligomannose structures; presence of complex, diantennary disialylated, non-fucosylated glycans; Disialylated fucosylated and monosialylated non-fucosylated oligosaccharides were also identified; Asn511, Asn700, Asn784, Asn804, Asn864, Asn893, Asn1011 and Asn1077 are glycosylated essentially by diantennary disialylated structures with a relative; absence of hybrid and oligomannose structures
Bomi257 P81282 Versican core protein VCAN 282662 MFGM, Exosome Glycosylated: As found in porcine, human and mouse,18 potential N-glycosylation sites; 22 potential O-glycosylation sites
Bomi263 O18738 Dystroglycan DAG1 281439 Whey heterodimeric glycoprotein- undergoes N-linked and extensive O-linked glycosylation; contains a large mucin-like domain with a number of Ser or Thr residues, which are potential sites for O-glycosylation; Dystroglycan also contains four potential N-linked glycosylation sites, three in -dystroglycan and one in Glycosylated: -dystroglycan ; The O-linked glycoconjugates contain a fairly unique sugar linkage where mannose is directly coupled to serine or threonine in the dystroglycan peptide
Bomi284 F1MW13 Deoxyribonuclease (Fragment) DNASE1L1 MFGM, Exosome Glycosylated: In humans, N-linked glycosylation at Asn-243- conserved in the corresponding regions of monkey, porcine and bovine DNase X proteins
Bomi29 Q2TBX4 Heat shock 70 kDa protein HSPA13 505907 Whey O glycosylation was found in HSP6, a member of HSP 70 family; presence of N-acetyl glucosamine
Bomi2973 E1BHI7 Butyrophilin subfamily 1 member A1 BTN1A1 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi302 P11151 Lipoprotein lipase LPL 280843 Whey, MFGM, Exosome Glycosylated: As found in bovine milk - 10 cysteine residues which are in disulfide bridges. Disulfide bonds are formed between Cys29 and Cys42, CYS 218 and Cys241,C266 and Cys285, C,YS277and Cys280",a nd Cys420 and CYS 440; residues Asn44 and 361 and were identified as potential N-glycosylation sites in bLPL
Bomi3090 F1MZQ4 Butyrophilin subfamily 1 member A1 BTN1A1 Whey N linked glycosylation in the exoplasmic domain; presence of mannaose, galactose and N-acetylglucosamine; 3 potential N-glycosylation sites - 2 in the -NH2 terminal and 1 in -COOH terminal; Acylation with myristate, stearate, palmitate and oleate
Bomi31 Q3SZV7 Hemopexin HPX 534509 Whey Glycosylated; N-linked glycosylation; mannose, galactose, sialic acids, glucosamine as found in serum hemopexin; virtual blocking of the amino terminus by a galactosamine oligosaccharide, presence of five attachment sites for glucosamine oligosaccharides, and four unusual clusters of tryptophan residues as found in humans
Bomi310 Q27960 Sodium-dependent phosphate transport protein 2B SLC34A2 282484 Whey, MFGM, Exosome Glycosylated:possible sites for N-glycosylation and phosphorylation by protein kinase C as found in bovine renal epithelial cells;
Bomi32 Q58D62 Fetuin FETUB 504615 Whey complex triantennary oligosaccharides; possesses considerable N-glycosylation site heterogeneity; asialo-fetuin contains two variant triantennary oligosaccharides with either Galß(l - 3)^3 or Galß(1 - 4) at one of the terminal branch positions; presence of sialylation heterogeneity among each of these oligosaccharides; contains 12 cysteines and makes 6 disulfide bonds
Bomi327 Q2KIW2 CD68 molecule CD68 504960 MFGM Glycosylated:As in mouse macrophage and similar to CD68- heavily glycosylated; nine potential N-linked glycosylation sites and numerous potential 0-linked glycosylation sites; approximately 40% from 0-linked and 20-25% from N-linked sugars, with only about one third coming from the polypeptide backbone
Bomi331 Q3SYR8 Immunoglobulin J chain JCHAIN 280821 Whey, MFGM, Exosome glycoprotein; N linked glycosylation at 39th aa in both bovine and humans; contains eight cysteine residues: two (cys15 and cys69) are involved in disulfide bridges with the α or µ chains; and six are involved in intrachain disulfide bridges
Bomi338 Q9TTF5 CD38 molecule CD38 327677 Exosome Glycosylated: potential N-linked glycosylation sites asparagine residues, N100, N164, N209 and N219
Bomi343 A6QNW6 Testis anion transporter 1 SLC26A8 530509 Exosome Glycoysltaed: As found in rats, four putative N-glycosylation sites in the major predicted external loop
Bomi351 Q5EA85 Semaphorin-4A SEMA4A 510239 Whey Glycosylated: consensus N-linked glycosylation sites a found in semaphorin 3F in the human nervous system
Bomi361 P98167 SCO-spondin SSPO 282659 Exosome Glycosylated: potent N-linked glycosylation sites
Bomi37 A2VE46 Chloride intracellular channel 2 CLIC2 532777 Exosome myristoylation, glycosylation and phosphorylation present either near the transmembrane domain or in the C-terminus
Bomi41 P46193 Annexin A1 ANXA1 327662 MFGM, Exosome phosphorylated by pkc as found in bocine mammary gland; glycosylated as found in human placenta - presence of N-acetyl-D-galactosamine residues, two cc-linked biantennary mannosyl residues, one site of asparagine-linked glycosylation which may contain two a-linked biantennary mannosyl residues; indicates a potential Nlinked glycosylation site at the 42nd position of its amino terminal region
Bomi44 Q3T0C6 Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 532844 MFGM ß domain has domain has three, eight, and two glycosylation sites in beta1, 2, and 3, respectively
Bomi46 Q95126 Activin receptor type-2B ACVR2B 282131 Exosome ActRIIB.Fc protein contains three potential N-glycosylation sites - two in the extracellular domain of ActRIIB and one in the Fc portion of the fusion molecule
Bomi5 P01030 Complement C4 C4 Whey Glycosylated: 4 N linked glycosylation site; α and ß-chains are glycosylated, but no accurate assessment of carbohydrate content in the γ-chain has been reported; C4 in human plasma contains mannose, galactose, glucosamine and sialic acid; contain complex biantennary glycans with varying degrees of sialylation; Human C4A recovered from cerebrospinal fluid was identified to contain an O-linked core 1 glycan; sulfation of three tyrosine residues
Bomi55 Q8HYR6 Dehydrogenase/reductase SDR family member 9 DHRS9 282851 MFGM No glycosylation motif
Bomi601 P17690 Beta-2-glycoprotein 1 APOH 281006 Whey, Exosome 19% (w/w) carbohydrates attached to N-linked glycosylation sites
Bomi7 P06394 Keratin, type I cytoskeletal 10 KRT10 281888 Whey undergo several posttranslational modifications (PTMs), including phosphorylation, O-linked glycosylation, ubiquitination, acetylation, SUMOylation, and transamidation; known keratin phosphorylation sites are serine/threonine residues that are located in the head and tail domains of the keratins; glycosylation of keratins also occurs on serine residues
Bomi90 P45879 Voltage-dependent anion-selective channel protein 1 VDAC1 282119 MFGM Glycosylation (O-GlcNAc) of VDAC2 has been shown in mouse embryonic fibroblasts; other post translational modification like Hypernitrosylation and phosphorylation in diseased conditions