BoMiProt is a manually curated, comprehensive repository of published information of bovine milk proteins. It provides a bird’s eye view of the on-going research on bovine milk and possible information gaps that needs attention for maximizing health promoting effects of milk and different dairy products. BoMiProt has over 10,000 proteins including unique BoMiProt IDs and primary information such as Uniprot ID, protein name, gene name and gene ID along with cross references to other databases. Over 1700 proteins named as ‘BoMiProt defined proteins’, are enriched with additional information about biological function, biochemical properties, post translational modifications (PTMs) and their role and significance in milk domains, folds, and predicted transmembrane helices, and disordered regions – all information collected from existing literature. Additionally, all entries were categorized based on which fractions they were collected, for example, whey, milk fat globule membrane (MFGM) and exosomes. This database aims to facilitate scientific explorations of the growing volume of data on milk proteome to the scientific community interested in health, nutrition, and disease attributes, seeking diverse applications and positively impacting animal and human health.
BoMiProt database provides curated data files that are downloadable. Additionally, it also allows a user to search protein entries based on several criteria for both primary and secondary information along with FASTA files. Structure gallery renders independently an easy retrieval of crystal structures and homology and AlphaFold models of BoMiProt defined proteins. A list of 41 publications have been used to curate the protein entries in the database which are available under links along with number of proteins identified and technical details. This version of BoMiProt represents an extensive compilation of newer proteins, including structural, functional, and hierarchical information, to help researchers better understand mammary gland pathophysiology, including their potential application in improving the nutritional quality of dairy products.
In the last 30 years, almost 70% of the researchers of bovine milk have focused on whey proteins followed by MFGM (20%) and exosomes (10%). View More